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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
USP3
Full Name:
Ubiquitin carboxyl-terminal hydrolase 3
Alias:
Deubiquitinating enzyme 3; SIH003; Ubiquitin specific peptidase 3; Ubiquitin specific protease 3; Ubiquitin thiolesterase 3; Ubiquitin-specific-processing protease 3; UBP; UBP3
Type:
EC 3.1.2.15; Ubiquitin conjugating system; Protease
Mass (Da):
58897
Number AA:
520
UniProt ID:
Q9Y6I4
International Prot ID:
IPI00002330
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
GO:0004221
GO:0004843
GO:0008270
PhosphoSite+
KinaseNET
Biological Process:
GO:0006511
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S9
E
C
P
H
L
S
S
S
V
C
I
A
P
D
S
Site 2
S16
S
V
C
I
A
P
D
S
A
K
F
P
N
G
S
Site 3
S23
S
A
K
F
P
N
G
S
P
S
S
W
C
C
S
Site 4
S30
S
P
S
S
W
C
C
S
V
C
R
S
N
K
S
Site 5
Y52
S
S
V
H
C
G
R
Y
V
N
G
H
A
K
K
Site 6
Y61
N
G
H
A
K
K
H
Y
E
D
A
Q
V
P
L
Site 7
T69
E
D
A
Q
V
P
L
T
N
H
K
K
S
E
K
Site 8
T83
K
Q
D
K
V
Q
H
T
V
C
M
D
C
S
S
Site 9
T93
M
D
C
S
S
Y
S
T
Y
C
Y
R
C
D
D
Site 10
Y94
D
C
S
S
Y
S
T
Y
C
Y
R
C
D
D
F
Site 11
Y96
S
S
Y
S
T
Y
C
Y
R
C
D
D
F
V
V
Site 12
S140
K
R
K
L
L
E
N
S
T
L
N
S
K
L
L
Site 13
T141
R
K
L
L
E
N
S
T
L
N
S
K
L
L
K
Site 14
S144
L
E
N
S
T
L
N
S
K
L
L
K
V
N
G
Site 15
T200
V
E
L
R
N
G
K
T
A
G
R
R
T
Y
H
Site 16
T205
G
K
T
A
G
R
R
T
Y
H
T
R
S
Q
G
Site 17
Y206
K
T
A
G
R
R
T
Y
H
T
R
S
Q
G
D
Site 18
T208
A
G
R
R
T
Y
H
T
R
S
Q
G
D
N
N
Site 19
S210
R
R
T
Y
H
T
R
S
Q
G
D
N
N
V
S
Site 20
S217
S
Q
G
D
N
N
V
S
L
V
E
E
F
R
K
Site 21
S233
L
C
A
L
W
Q
G
S
Q
T
A
F
S
P
E
Site 22
S238
Q
G
S
Q
T
A
F
S
P
E
S
L
F
Y
V
Site 23
Y256
I
M
P
N
F
R
G
Y
Q
Q
Q
D
A
H
E
Site 24
Y267
D
A
H
E
F
M
R
Y
L
L
D
H
L
H
L
Site 25
S284
Q
G
G
F
N
G
V
S
R
S
A
I
L
Q
E
Site 26
S286
G
F
N
G
V
S
R
S
A
I
L
Q
E
N
S
Site 27
T294
A
I
L
Q
E
N
S
T
L
S
A
S
N
K
C
Site 28
S296
L
Q
E
N
S
T
L
S
A
S
N
K
C
C
I
Site 29
S346
D
L
S
L
D
I
P
S
Q
F
R
S
K
R
S
Site 30
S350
D
I
P
S
Q
F
R
S
K
R
S
K
N
Q
E
Site 31
S363
Q
E
N
G
P
V
C
S
L
R
D
C
L
R
S
Site 32
S370
S
L
R
D
C
L
R
S
F
T
D
L
E
E
L
Site 33
T372
R
D
C
L
R
S
F
T
D
L
E
E
L
D
E
Site 34
T380
D
L
E
E
L
D
E
T
E
L
Y
M
C
H
K
Site 35
Y383
E
L
D
E
T
E
L
Y
M
C
H
K
C
K
K
Site 36
Y419
K
R
F
H
W
T
A
Y
L
R
N
K
V
D
T
Site 37
T426
Y
L
R
N
K
V
D
T
Y
V
E
F
P
L
R
Site 38
Y427
L
R
N
K
V
D
T
Y
V
E
F
P
L
R
G
Site 39
Y440
R
G
L
D
M
K
C
Y
L
L
E
P
E
N
S
Site 40
S447
Y
L
L
E
P
E
N
S
G
P
E
S
C
L
Y
Site 41
S451
P
E
N
S
G
P
E
S
C
L
Y
D
L
A
A
Site 42
S469
H
H
G
S
G
V
G
S
G
H
Y
T
A
Y
A
Site 43
Y472
S
G
V
G
S
G
H
Y
T
A
Y
A
T
H
E
Site 44
T473
G
V
G
S
G
H
Y
T
A
Y
A
T
H
E
G
Site 45
Y475
G
S
G
H
Y
T
A
Y
A
T
H
E
G
R
W
Site 46
T489
W
F
H
F
N
D
S
T
V
T
L
T
D
E
E
Site 47
T497
V
T
L
T
D
E
E
T
V
V
K
A
K
A
Y
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation