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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
CABIN1
Full Name:
Calcineurin-binding protein cabin-1
Alias:
CABIN; CAIN; Calcineurin inhibitor
Type:
Transcription, coactivator/corepressor
Mass (Da):
246352
Number AA:
2220
UniProt ID:
Q9Y6J0
International Prot ID:
IPI00002355
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0004864
PhosphoSite+
KinaseNET
Biological Process:
GO:0007166
GO:0016568
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S20
I
E
D
D
H
E
G
S
F
K
S
H
K
T
Q
Site 2
S23
D
H
E
G
S
F
K
S
H
K
T
Q
T
K
E
Site 3
Y59
F
E
E
S
A
K
A
Y
H
E
L
L
E
A
S
Site 4
S66
Y
H
E
L
L
E
A
S
L
L
R
E
A
V
S
Site 5
S73
S
L
L
R
E
A
V
S
S
G
D
E
K
E
G
Site 6
S74
L
L
R
E
A
V
S
S
G
D
E
K
E
G
L
Site 7
S91
P
G
L
I
L
K
Y
S
T
Y
K
N
L
A
Q
Site 8
T108
A
Q
R
E
D
L
E
T
A
M
E
F
Y
L
E
Site 9
T122
E
A
V
M
L
D
S
T
D
V
N
L
W
Y
K
Site 10
Y191
A
L
E
K
D
C
R
Y
S
K
G
L
V
L
K
Site 11
S192
L
E
K
D
C
R
Y
S
K
G
L
V
L
K
E
Site 12
S212
Q
P
C
L
R
K
D
S
L
R
M
F
L
K
C
Site 13
S227
D
M
S
I
H
D
V
S
V
S
A
A
E
T
Q
Site 14
T285
L
A
M
Y
N
H
L
T
T
C
E
P
P
R
P
Site 15
T286
A
M
Y
N
H
L
T
T
C
E
P
P
R
P
S
Site 16
S293
T
C
E
P
P
R
P
S
L
G
K
R
I
D
L
Site 17
S301
L
G
K
R
I
D
L
S
D
Y
Q
D
P
S
Q
Site 18
Y303
K
R
I
D
L
S
D
Y
Q
D
P
S
Q
P
L
Site 19
S307
L
S
D
Y
Q
D
P
S
Q
P
L
E
S
S
M
Site 20
S312
D
P
S
Q
P
L
E
S
S
M
V
V
T
P
V
Site 21
S313
P
S
Q
P
L
E
S
S
M
V
V
T
P
V
N
Site 22
S325
P
V
N
V
I
Q
P
S
T
V
S
T
N
P
A
Site 23
T348
S
Y
T
S
V
A
T
T
S
F
P
L
H
S
P
Site 24
S349
Y
T
S
V
A
T
T
S
F
P
L
H
S
P
G
Site 25
S354
T
T
S
F
P
L
H
S
P
G
L
L
E
T
G
Site 26
S368
G
A
P
V
G
D
I
S
G
G
D
K
S
K
K
Site 27
S373
D
I
S
G
G
D
K
S
K
K
G
V
K
R
K
Site 28
T389
I
S
E
E
S
G
E
T
A
K
R
R
S
A
R
Site 29
S394
G
E
T
A
K
R
R
S
A
R
V
R
N
T
K
Site 30
T400
R
S
A
R
V
R
N
T
K
C
K
K
E
E
K
Site 31
S420
L
L
M
K
F
L
P
S
R
L
R
K
L
D
P
Site 32
S433
D
P
E
E
E
D
D
S
F
N
N
Y
E
V
Q
Site 33
Y437
E
D
D
S
F
N
N
Y
E
V
Q
S
E
A
K
Site 34
S447
Q
S
E
A
K
L
E
S
F
P
S
I
G
P
Q
Site 35
S450
A
K
L
E
S
F
P
S
I
G
P
Q
R
L
S
Site 36
S457
S
I
G
P
Q
R
L
S
F
D
S
A
T
F
M
Site 37
S460
P
Q
R
L
S
F
D
S
A
T
F
M
E
S
E
Site 38
T462
R
L
S
F
D
S
A
T
F
M
E
S
E
K
Q
Site 39
T480
E
F
L
L
E
N
L
T
N
G
G
I
L
E
L
Site 40
Y491
I
L
E
L
M
M
R
Y
L
K
A
M
G
H
K
Site 41
S513
G
L
A
E
V
V
L
S
V
Y
H
S
W
R
R
Site 42
Y515
A
E
V
V
L
S
V
Y
H
S
W
R
R
H
S
Site 43
S517
V
V
L
S
V
Y
H
S
W
R
R
H
S
T
S
Site 44
S522
Y
H
S
W
R
R
H
S
T
S
L
P
N
P
L
Site 45
T523
H
S
W
R
R
H
S
T
S
L
P
N
P
L
L
Site 46
S524
S
W
R
R
H
S
T
S
L
P
N
P
L
L
R
Site 47
T559
Q
L
D
Q
W
L
L
T
K
G
R
S
S
A
V
Site 48
S563
W
L
L
T
K
G
R
S
S
A
V
S
P
R
N
Site 49
S564
L
L
T
K
G
R
S
S
A
V
S
P
R
N
C
Site 50
S567
K
G
R
S
S
A
V
S
P
R
N
C
P
A
G
Site 51
S597
L
G
D
L
L
Q
L
S
F
A
S
S
Q
R
D
Site 52
S601
L
Q
L
S
F
A
S
S
Q
R
D
L
F
E
D
Site 53
T642
L
E
N
Y
D
I
C
T
E
M
L
Q
S
S
T
Site 54
S673
L
P
N
L
H
N
D
S
V
V
S
L
E
E
I
Site 55
S686
E
I
D
K
N
L
K
S
L
E
R
C
Q
S
L
Site 56
S692
K
S
L
E
R
C
Q
S
L
E
E
I
Q
R
L
Site 57
Y700
L
E
E
I
Q
R
L
Y
E
A
G
D
Y
K
A
Site 58
S732
K
H
L
E
F
M
T
S
I
P
E
R
P
A
Q
Site 59
Y753
S
L
L
R
L
K
D
Y
R
Q
C
F
E
C
S
Site 60
S802
E
Q
A
L
S
A
D
S
S
G
S
I
L
K
V
Site 61
S805
L
S
A
D
S
S
G
S
I
L
K
V
S
S
S
Site 62
S830
L
I
Q
V
I
D
C
S
M
A
V
Q
E
E
A
Site 63
S880
N
P
A
E
E
G
M
S
E
T
P
M
L
P
S
Site 64
T882
A
E
E
G
M
S
E
T
P
M
L
P
S
S
L
Site 65
T894
S
S
L
M
L
L
N
T
A
H
E
Y
L
G
R
Site 66
Y898
L
L
N
T
A
H
E
Y
L
G
R
R
S
W
C
Site 67
Y916
D
G
A
L
L
R
F
Y
V
R
V
L
Q
K
E
Site 68
S927
L
Q
K
E
L
A
A
S
T
S
E
D
T
H
P
Site 69
S929
K
E
L
A
A
S
T
S
E
D
T
H
P
Y
K
Site 70
T941
P
Y
K
E
E
L
E
T
A
L
E
Q
C
F
Y
Site 71
Y948
T
A
L
E
Q
C
F
Y
C
L
Y
S
F
P
S
Site 72
Y951
E
Q
C
F
Y
C
L
Y
S
F
P
S
K
K
S
Site 73
S955
Y
C
L
Y
S
F
P
S
K
K
S
K
A
R
Y
Site 74
S958
Y
S
F
P
S
K
K
S
K
A
R
Y
L
E
E
Site 75
Y962
S
K
K
S
K
A
R
Y
L
E
E
H
S
A
Q
Site 76
Y984
D
A
L
F
M
F
E
Y
F
K
P
K
T
L
P
Site 77
T989
F
E
Y
F
K
P
K
T
L
P
E
F
D
S
Y
Site 78
S995
K
T
L
P
E
F
D
S
Y
K
T
S
T
V
S
Site 79
Y996
T
L
P
E
F
D
S
Y
K
T
S
T
V
S
A
Site 80
T998
P
E
F
D
S
Y
K
T
S
T
V
S
A
D
L
Site 81
S999
E
F
D
S
Y
K
T
S
T
V
S
A
D
L
A
Site 82
T1000
F
D
S
Y
K
T
S
T
V
S
A
D
L
A
N
Site 83
T1014
N
L
L
K
R
I
A
T
I
V
P
R
T
E
R
Site 84
S1025
R
T
E
R
P
A
L
S
L
D
K
V
S
A
Y
Site 85
Y1032
S
L
D
K
V
S
A
Y
I
E
G
T
S
T
E
Site 86
T1038
A
Y
I
E
G
T
S
T
E
V
P
C
L
P
E
Site 87
S1050
L
P
E
G
A
D
P
S
P
P
V
V
N
E
L
Site 88
Y1064
L
Y
Y
L
L
A
D
Y
H
F
K
N
K
E
Q
Site 89
S1101
G
M
A
L
A
R
A
S
R
I
Q
D
K
L
N
Site 90
S1114
L
N
S
N
E
L
K
S
D
G
P
I
W
K
H
Site 91
S1137
R
R
A
L
E
I
D
S
S
N
L
S
L
W
I
Site 92
S1138
R
A
L
E
I
D
S
S
N
L
S
L
W
I
E
Site 93
S1141
E
I
D
S
S
N
L
S
L
W
I
E
Y
G
T
Site 94
T1148
S
L
W
I
E
Y
G
T
M
S
Y
A
L
H
S
Site 95
S1155
T
M
S
Y
A
L
H
S
F
A
S
R
Q
L
K
Site 96
S1158
Y
A
L
H
S
F
A
S
R
Q
L
K
Q
W
R
Site 97
S1182
Q
M
E
G
R
R
D
S
M
L
E
T
A
K
H
Site 98
T1186
R
R
D
S
M
L
E
T
A
K
H
C
F
T
S
Site 99
Y1210
E
E
E
W
L
I
H
Y
M
L
G
K
V
A
E
Site 100
T1224
E
K
Q
Q
Q
P
P
T
V
Y
L
L
H
Y
R
Site 101
Y1230
P
T
V
Y
L
L
H
Y
R
Q
A
G
H
Y
L
Site 102
Y1236
H
Y
R
Q
A
G
H
Y
L
H
E
E
A
A
R
Site 103
Y1244
L
H
E
E
A
A
R
Y
P
K
K
I
H
Y
H
Site 104
Y1250
R
Y
P
K
K
I
H
Y
H
N
P
P
E
L
A
Site 105
T1307
A
R
G
E
E
K
N
T
P
K
A
S
E
K
E
Site 106
S1323
A
C
L
V
D
E
D
S
H
S
S
A
G
T
L
Site 107
S1325
L
V
D
E
D
S
H
S
S
A
G
T
L
P
G
Site 108
T1329
D
S
H
S
S
A
G
T
L
P
G
P
G
A
S
Site 109
S1336
T
L
P
G
P
G
A
S
L
P
S
S
S
G
P
Site 110
S1339
G
P
G
A
S
L
P
S
S
S
G
P
G
L
T
Site 111
S1340
P
G
A
S
L
P
S
S
S
G
P
G
L
T
S
Site 112
S1341
G
A
S
L
P
S
S
S
G
P
G
L
T
S
P
Site 113
T1346
S
S
S
G
P
G
L
T
S
P
P
Y
T
A
T
Site 114
S1347
S
S
G
P
G
L
T
S
P
P
Y
T
A
T
P
Site 115
Y1350
P
G
L
T
S
P
P
Y
T
A
T
P
I
D
H
Site 116
T1351
G
L
T
S
P
P
Y
T
A
T
P
I
D
H
D
Site 117
T1353
T
S
P
P
Y
T
A
T
P
I
D
H
D
Y
V
Site 118
Y1359
A
T
P
I
D
H
D
Y
V
K
C
K
K
P
H
Site 119
T1370
K
K
P
H
Q
Q
A
T
P
D
D
R
S
Q
D
Site 120
S1375
Q
A
T
P
D
D
R
S
Q
D
S
T
A
V
A
Site 121
S1378
P
D
D
R
S
Q
D
S
T
A
V
A
L
S
D
Site 122
T1379
D
D
R
S
Q
D
S
T
A
V
A
L
S
D
S
Site 123
S1384
D
S
T
A
V
A
L
S
D
S
S
S
T
Q
D
Site 124
S1386
T
A
V
A
L
S
D
S
S
S
T
Q
D
F
F
Site 125
S1388
V
A
L
S
D
S
S
S
T
Q
D
F
F
N
E
Site 126
S1398
D
F
F
N
E
P
T
S
L
L
E
G
S
R
K
Site 127
S1406
L
L
E
G
S
R
K
S
Y
T
E
K
R
L
P
Site 128
Y1407
L
E
G
S
R
K
S
Y
T
E
K
R
L
P
I
Site 129
T1408
E
G
S
R
K
S
Y
T
E
K
R
L
P
I
L
Site 130
S1416
E
K
R
L
P
I
L
S
S
Q
A
G
A
T
G
Site 131
S1417
K
R
L
P
I
L
S
S
Q
A
G
A
T
G
K
Site 132
S1439
E
R
G
K
N
E
E
S
L
E
S
T
E
G
F
Site 133
S1442
K
N
E
E
S
L
E
S
T
E
G
F
R
A
A
Site 134
T1460
V
Q
K
P
A
A
E
T
P
A
S
A
C
I
P
Site 135
S1463
P
A
A
E
T
P
A
S
A
C
I
P
G
K
P
Site 136
S1471
A
C
I
P
G
K
P
S
A
S
T
P
T
L
W
Site 137
S1473
I
P
G
K
P
S
A
S
T
P
T
L
W
D
G
Site 138
T1474
P
G
K
P
S
A
S
T
P
T
L
W
D
G
K
Site 139
S1521
A
S
F
R
L
C
L
S
R
F
P
Q
H
Y
K
Site 140
Y1527
L
S
R
F
P
Q
H
Y
K
S
L
Y
R
L
A
Site 141
S1529
R
F
P
Q
H
Y
K
S
L
Y
R
L
A
F
L
Site 142
Y1531
P
Q
H
Y
K
S
L
Y
R
L
A
F
L
Y
T
Site 143
Y1537
L
Y
R
L
A
F
L
Y
T
Y
S
K
T
H
R
Site 144
T1538
Y
R
L
A
F
L
Y
T
Y
S
K
T
H
R
N
Site 145
S1540
L
A
F
L
Y
T
Y
S
K
T
H
R
N
L
Q
Site 146
S1605
F
A
W
H
M
N
R
S
I
V
L
L
L
K
V
Site 147
S1620
L
A
Q
L
R
D
H
S
T
L
L
K
V
S
S
Site 148
T1621
A
Q
L
R
D
H
S
T
L
L
K
V
S
S
M
Site 149
S1627
S
T
L
L
K
V
S
S
M
L
Q
R
T
P
D
Site 150
T1632
V
S
S
M
L
Q
R
T
P
D
Q
G
K
K
Y
Site 151
Y1639
T
P
D
Q
G
K
K
Y
L
R
D
A
D
R
Q
Site 152
T1663
T
V
K
V
L
E
D
T
L
S
E
L
A
E
G
Site 153
S1665
K
V
L
E
D
T
L
S
E
L
A
E
G
S
E
Site 154
S1671
L
S
E
L
A
E
G
S
E
R
P
G
P
K
V
Site 155
T1687
G
L
P
G
A
R
M
T
T
D
V
S
H
K
A
Site 156
T1688
L
P
G
A
R
M
T
T
D
V
S
H
K
A
S
Site 157
S1691
A
R
M
T
T
D
V
S
H
K
A
S
P
E
D
Site 158
S1695
T
D
V
S
H
K
A
S
P
E
D
G
Q
E
G
Site 159
S1715
K
P
P
L
A
D
G
S
G
P
G
P
E
P
G
Site 160
S1740
V
A
M
D
A
G
D
S
A
D
Q
S
G
E
R
Site 161
S1744
A
G
D
S
A
D
Q
S
G
E
R
K
D
K
E
Site 162
S1752
G
E
R
K
D
K
E
S
P
R
A
G
P
T
E
Site 163
T1763
G
P
T
E
P
M
D
T
S
E
A
T
V
C
H
Site 164
S1764
P
T
E
P
M
D
T
S
E
A
T
V
C
H
S
Site 165
T1767
P
M
D
T
S
E
A
T
V
C
H
S
D
L
E
Site 166
S1771
S
E
A
T
V
C
H
S
D
L
E
R
T
P
P
Site 167
T1776
C
H
S
D
L
E
R
T
P
P
L
L
P
G
R
Site 168
S1792
A
R
D
R
G
P
E
S
R
P
T
E
L
S
L
Site 169
T1795
R
G
P
E
S
R
P
T
E
L
S
L
E
E
L
Site 170
S1798
E
S
R
P
T
E
L
S
L
E
E
L
S
I
S
Site 171
S1803
E
L
S
L
E
E
L
S
I
S
A
R
Q
Q
P
Site 172
S1805
S
L
E
E
L
S
I
S
A
R
Q
Q
P
T
P
Site 173
T1811
I
S
A
R
Q
Q
P
T
P
L
T
P
A
Q
P
Site 174
T1814
R
Q
Q
P
T
P
L
T
P
A
Q
P
A
P
A
Site 175
S1841
G
H
P
E
E
P
L
S
R
L
S
R
K
R
K
Site 176
S1844
E
E
P
L
S
R
L
S
R
K
R
K
L
L
E
Site 177
T1853
K
R
K
L
L
E
D
T
E
S
G
K
T
L
L
Site 178
S1855
K
L
L
E
D
T
E
S
G
K
T
L
L
L
D
Site 179
T1858
E
D
T
E
S
G
K
T
L
L
L
D
A
Y
R
Site 180
Y1864
K
T
L
L
L
D
A
Y
R
V
W
Q
Q
G
Q
Site 181
Y1876
Q
G
Q
K
G
V
A
Y
D
L
G
R
V
E
R
Site 182
S1886
G
R
V
E
R
I
M
S
E
T
Y
M
L
I
K
Site 183
S1921
A
A
A
Q
R
Q
A
S
G
D
T
P
T
T
P
Site 184
T1924
Q
R
Q
A
S
G
D
T
P
T
T
P
K
H
P
Site 185
T1926
Q
A
S
G
D
T
P
T
T
P
K
H
P
K
D
Site 186
T1927
A
S
G
D
T
P
T
T
P
K
H
P
K
D
S
Site 187
S1934
T
P
K
H
P
K
D
S
R
E
N
F
F
P
V
Site 188
T1942
R
E
N
F
F
P
V
T
V
V
P
T
A
P
D
Site 189
S1955
P
D
P
V
P
A
D
S
V
Q
R
P
S
D
A
Site 190
S1960
A
D
S
V
Q
R
P
S
D
A
H
T
K
P
R
Site 191
T1964
Q
R
P
S
D
A
H
T
K
P
R
P
A
L
A
Site 192
S1984
I
T
C
P
P
S
A
S
A
S
T
L
D
Q
S
Site 193
S1986
C
P
P
S
A
S
A
S
T
L
D
Q
S
K
D
Site 194
S1991
S
A
S
T
L
D
Q
S
K
D
P
G
P
P
R
Site 195
T2005
R
P
H
R
P
E
A
T
P
S
M
A
S
L
G
Site 196
S2007
H
R
P
E
A
T
P
S
M
A
S
L
G
P
E
Site 197
S2010
E
A
T
P
S
M
A
S
L
G
P
E
G
E
E
Site 198
S2026
A
R
V
A
E
G
T
S
F
P
P
Q
E
P
R
Site 199
S2035
P
P
Q
E
P
R
H
S
P
Q
V
K
M
A
P
Site 200
S2044
Q
V
K
M
A
P
T
S
S
P
A
E
P
H
C
Site 201
S2045
V
K
M
A
P
T
S
S
P
A
E
P
H
C
W
Site 202
T2065
L
G
T
G
A
E
P
T
C
S
Q
E
G
K
L
Site 203
S2067
T
G
A
E
P
T
C
S
Q
E
G
K
L
R
P
Site 204
S2087
G
E
A
Q
E
A
A
S
E
T
Q
P
L
S
S
Site 205
T2089
A
Q
E
A
A
S
E
T
Q
P
L
S
S
P
P
Site 206
S2093
A
S
E
T
Q
P
L
S
S
P
P
T
A
A
S
Site 207
S2094
S
E
T
Q
P
L
S
S
P
P
T
A
A
S
S
Site 208
T2097
Q
P
L
S
S
P
P
T
A
A
S
S
K
A
P
Site 209
S2100
S
S
P
P
T
A
A
S
S
K
A
P
S
S
G
Site 210
S2101
S
P
P
T
A
A
S
S
K
A
P
S
S
G
S
Site 211
S2105
A
A
S
S
K
A
P
S
S
G
S
A
Q
P
P
Site 212
S2106
A
S
S
K
A
P
S
S
G
S
A
Q
P
P
E
Site 213
S2108
S
K
A
P
S
S
G
S
A
Q
P
P
E
G
H
Site 214
S2122
H
P
G
K
P
E
P
S
R
A
K
S
R
P
L
Site 215
S2126
P
E
P
S
R
A
K
S
R
P
L
P
N
M
P
Site 216
T2142
L
V
I
P
S
A
A
T
K
F
P
P
E
I
T
Site 217
T2149
T
K
F
P
P
E
I
T
V
T
P
P
T
P
T
Site 218
T2151
F
P
P
E
I
T
V
T
P
P
T
P
T
L
L
Site 219
T2154
E
I
T
V
T
P
P
T
P
T
L
L
S
P
K
Site 220
T2156
T
V
T
P
P
T
P
T
L
L
S
P
K
G
S
Site 221
S2159
P
P
T
P
T
L
L
S
P
K
G
S
I
S
E
Site 222
S2163
T
L
L
S
P
K
G
S
I
S
E
E
T
K
Q
Site 223
S2165
L
S
P
K
G
S
I
S
E
E
T
K
Q
K
L
Site 224
S2174
E
T
K
Q
K
L
K
S
A
I
L
S
A
Q
S
Site 225
S2181
S
A
I
L
S
A
Q
S
A
A
N
V
R
K
E
Site 226
S2189
A
A
N
V
R
K
E
S
L
C
Q
P
A
L
E
Site 227
T2200
P
A
L
E
V
L
E
T
S
S
Q
E
S
S
L
Site 228
S2201
A
L
E
V
L
E
T
S
S
Q
E
S
S
L
E
Site 229
S2202
L
E
V
L
E
T
S
S
Q
E
S
S
L
E
S
Site 230
S2205
L
E
T
S
S
Q
E
S
S
L
E
S
E
T
D
Site 231
S2206
E
T
S
S
Q
E
S
S
L
E
S
E
T
D
E
Site 232
S2209
S
Q
E
S
S
L
E
S
E
T
D
E
D
D
D
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation