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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
DNMT3A
Full Name:
DNA (cytosine-5)-methyltransferase 3A
Alias:
DNA cytosine methyltransferase 3 alpha; DNA cytosine methyltransferase 3A2; DNA methyltransferase HsaIIIA; DNA MTase HsaIIIA; DNM3A; DNMT3A2; EC 2.1.1.37; M.HsaIIIA
Type:
Methyltransferase; EC 2.1.1.37; Amino Acid Metabolism - cysteine and methionine
Mass (Da):
101858
Number AA:
912
UniProt ID:
Q9Y6K1
International Prot ID:
IPI00220006
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0000791
GO:0016363
Uniprot
OncoNet
Molecular Function:
GO:0003886
GO:0003677
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0006306
GO:0006349
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S7
_
M
P
A
M
P
S
S
G
P
G
D
T
S
S
Site 2
S13
S
S
G
P
G
D
T
S
S
S
A
A
E
R
E
Site 3
S14
S
G
P
G
D
T
S
S
S
A
A
E
R
E
E
Site 4
S15
G
P
G
D
T
S
S
S
A
A
E
R
E
E
D
Site 5
T43
E
E
R
Q
E
P
S
T
T
A
R
K
V
G
R
Site 6
T44
E
R
Q
E
P
S
T
T
A
R
K
V
G
R
P
Site 7
T65
P
P
V
E
S
G
D
T
P
K
D
P
A
V
I
Site 8
S73
P
K
D
P
A
V
I
S
K
S
P
S
M
A
Q
Site 9
S75
D
P
A
V
I
S
K
S
P
S
M
A
Q
D
S
Site 10
S77
A
V
I
S
K
S
P
S
M
A
Q
D
S
G
A
Site 11
S82
S
P
S
M
A
Q
D
S
G
A
S
E
L
L
P
Site 12
S97
N
G
D
L
E
K
R
S
E
P
Q
P
E
E
G
Site 13
S105
E
P
Q
P
E
E
G
S
P
A
G
G
Q
K
G
Site 14
T124
E
G
E
G
A
A
E
T
L
P
E
A
S
R
A
Site 15
T138
A
V
E
N
G
C
C
T
P
K
E
G
R
G
A
Site 16
T156
A
G
K
E
Q
K
E
T
N
I
E
S
M
K
M
Site 17
S160
Q
K
E
T
N
I
E
S
M
K
M
E
G
S
R
Site 18
S166
E
S
M
K
M
E
G
S
R
G
R
L
R
G
G
Site 19
S178
R
G
G
L
G
W
E
S
S
L
R
Q
R
P
M
Site 20
S179
G
G
L
G
W
E
S
S
L
R
Q
R
P
M
P
Site 21
T189
Q
R
P
M
P
R
L
T
F
Q
A
G
D
P
Y
Site 22
Y196
T
F
Q
A
G
D
P
Y
Y
I
S
K
R
K
R
Site 23
Y197
F
Q
A
G
D
P
Y
Y
I
S
K
R
K
R
D
Site 24
S236
E
N
Q
G
P
G
E
S
Q
K
V
E
E
A
S
Site 25
S243
S
Q
K
V
E
E
A
S
P
P
A
V
Q
Q
P
Site 26
T251
P
P
A
V
Q
Q
P
T
D
P
A
S
P
T
V
Site 27
S255
Q
Q
P
T
D
P
A
S
P
T
V
A
T
T
P
Site 28
T257
P
T
D
P
A
S
P
T
V
A
T
T
P
E
P
Site 29
T261
A
S
P
T
V
A
T
T
P
E
P
V
G
S
D
Site 30
S267
T
T
P
E
P
V
G
S
D
A
G
D
K
N
A
Site 31
Y284
A
G
D
D
E
P
E
Y
E
D
G
R
G
F
G
Site 32
T316
R
I
V
S
W
W
M
T
G
R
S
R
A
A
E
Site 33
S349
E
K
L
M
P
L
S
S
F
C
S
A
F
H
Q
Site 34
Y359
S
A
F
H
Q
A
T
Y
N
K
Q
P
M
Y
R
Site 35
Y365
T
Y
N
K
Q
P
M
Y
R
K
A
I
Y
E
V
Site 36
S377
Y
E
V
L
Q
V
A
S
S
R
A
G
K
L
F
Site 37
S390
L
F
P
V
C
H
D
S
D
E
S
D
T
A
K
Site 38
S393
V
C
H
D
S
D
E
S
D
T
A
K
A
V
E
Site 39
S417
A
L
G
G
F
Q
P
S
G
P
K
G
L
E
P
Site 40
Y432
P
E
E
E
K
N
P
Y
K
E
V
Y
T
D
M
Site 41
Y448
V
E
P
E
A
A
A
Y
A
P
P
P
P
A
K
Site 42
S460
P
A
K
K
P
R
K
S
T
A
E
K
P
K
V
Site 43
T461
A
K
K
P
R
K
S
T
A
E
K
P
K
V
K
Site 44
Y481
R
T
R
E
R
L
V
Y
E
V
R
Q
K
C
R
Site 45
Y526
N
C
F
L
E
C
A
Y
Q
Y
D
D
D
G
Y
Site 46
Y528
F
L
E
C
A
Y
Q
Y
D
D
D
G
Y
Q
S
Site 47
Y533
Y
Q
Y
D
D
D
G
Y
Q
S
Y
C
T
I
C
Site 48
Y536
D
D
D
G
Y
Q
S
Y
C
T
I
C
C
G
G
Site 49
S603
R
R
R
E
D
W
P
S
R
L
Q
M
F
F
A
Site 50
Y623
E
F
D
P
P
K
V
Y
P
P
V
P
A
E
K
Site 51
S638
R
K
P
I
R
V
L
S
L
F
D
G
I
A
T
Site 52
T645
S
L
F
D
G
I
A
T
G
L
L
V
L
K
D
Site 53
T671
E
V
C
E
D
S
I
T
V
G
M
V
R
H
Q
Site 54
Y683
R
H
Q
G
K
I
M
Y
V
G
D
V
R
S
V
Site 55
T691
V
G
D
V
R
S
V
T
Q
K
H
I
Q
E
W
Site 56
S714
G
S
P
C
N
D
L
S
I
V
N
P
A
R
K
Site 57
Y724
N
P
A
R
K
G
L
Y
E
G
T
G
R
L
F
Site 58
T727
R
K
G
L
Y
E
G
T
G
R
L
F
F
E
F
Site 59
S770
V
S
D
K
R
D
I
S
R
F
L
E
S
N
P
Site 60
Y793
S
A
A
H
R
A
R
Y
F
W
G
N
L
P
G
Site 61
T808
M
N
R
P
L
A
S
T
V
N
D
K
L
E
L
Site 62
S828
H
G
R
I
A
K
F
S
K
V
R
T
I
T
T
Site 63
T832
A
K
F
S
K
V
R
T
I
T
T
R
S
N
S
Site 64
T834
F
S
K
V
R
T
I
T
T
R
S
N
S
I
K
Site 65
T835
S
K
V
R
T
I
T
T
R
S
N
S
I
K
Q
Site 66
S839
T
I
T
T
R
S
N
S
I
K
Q
G
K
D
Q
Site 67
S878
P
V
H
Y
T
D
V
S
N
M
S
R
L
A
R
Site 68
S892
R
Q
R
L
L
G
R
S
W
S
V
P
V
I
R
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation