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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
AK5
Full Name:
Adenylate kinase isoenzyme 5
Alias:
ATP-AMP transphosphorylase 5
Type:
Mass (Da):
63333
Number AA:
562
UniProt ID:
Q9Y6K8
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y9
N
T
N
D
A
K
E
Y
L
A
R
R
E
I
P
Site 2
S29
L
L
N
G
L
M
C
S
K
P
E
D
P
V
E
Site 3
Y37
K
P
E
D
P
V
E
Y
L
E
S
C
L
Q
K
Site 4
T58
C
D
K
V
K
W
D
T
F
V
S
Q
E
K
K
Site 5
S61
V
K
W
D
T
F
V
S
Q
E
K
K
T
L
P
Site 6
T66
F
V
S
Q
E
K
K
T
L
P
P
L
N
G
G
Site 7
S75
P
P
L
N
G
G
Q
S
R
R
S
F
L
R
N
Site 8
S78
N
G
G
Q
S
R
R
S
F
L
R
N
V
M
P
Site 9
Y92
P
E
N
S
N
F
P
Y
R
R
Y
D
R
L
P
Site 10
Y95
S
N
F
P
Y
R
R
Y
D
R
L
P
P
I
H
Site 11
S105
L
P
P
I
H
Q
F
S
I
E
S
D
T
D
L
Site 12
S108
I
H
Q
F
S
I
E
S
D
T
D
L
S
E
T
Site 13
S113
I
E
S
D
T
D
L
S
E
T
A
E
L
I
E
Site 14
Y122
T
A
E
L
I
E
E
Y
E
V
F
D
P
T
R
Site 15
T128
E
Y
E
V
F
D
P
T
R
P
R
P
K
I
I
Site 16
S143
L
V
I
G
G
P
G
S
G
K
G
T
Q
S
L
Site 17
T147
G
P
G
S
G
K
G
T
Q
S
L
K
I
A
E
Site 18
S149
G
S
G
K
G
T
Q
S
L
K
I
A
E
R
Y
Site 19
S162
R
Y
G
F
Q
Y
I
S
V
G
E
L
L
R
K
Site 20
S173
L
L
R
K
K
I
H
S
T
S
S
N
R
K
W
Site 21
S175
R
K
K
I
H
S
T
S
S
N
R
K
W
S
L
Site 22
S176
K
K
I
H
S
T
S
S
N
R
K
W
S
L
I
Site 23
S181
T
S
S
N
R
K
W
S
L
I
A
K
I
I
T
Site 24
T200
A
P
Q
E
T
T
I
T
E
I
K
Q
K
L
M
Site 25
S229
R
D
V
A
Q
A
L
S
F
E
D
Q
I
C
T
Site 26
T271
P
D
D
N
V
K
A
T
Q
R
R
L
M
N
F
Site 27
S335
G
S
S
D
L
D
P
S
M
I
L
D
T
G
E
Site 28
T346
D
T
G
E
I
I
D
T
G
S
D
Y
E
D
Q
Site 29
S348
G
E
I
I
D
T
G
S
D
Y
E
D
Q
G
D
Site 30
Y350
I
I
D
T
G
S
D
Y
E
D
Q
G
D
D
Q
Site 31
T365
L
N
V
F
G
E
D
T
M
G
G
F
M
E
D
Site 32
S387
F
I
I
G
G
P
G
S
G
K
G
T
Q
C
E
Site 33
T391
G
P
G
S
G
K
G
T
Q
C
E
K
L
V
E
Site 34
S406
K
Y
G
F
T
H
L
S
T
G
E
L
L
R
E
Site 35
S417
L
L
R
E
E
L
A
S
E
S
E
R
S
K
L
Site 36
S419
R
E
E
L
A
S
E
S
E
R
S
K
L
I
R
Site 37
S422
L
A
S
E
S
E
R
S
K
L
I
R
D
I
M
Site 38
Y463
R
G
F
L
I
D
G
Y
P
R
E
V
K
Q
G
Site 39
T494
D
C
S
A
D
T
M
T
N
R
L
L
Q
R
S
Site 40
S501
T
N
R
L
L
Q
R
S
R
S
S
L
P
V
D
Site 41
S503
R
L
L
Q
R
S
R
S
S
L
P
V
D
D
T
Site 42
S504
L
L
Q
R
S
R
S
S
L
P
V
D
D
T
T
Site 43
T510
S
S
L
P
V
D
D
T
T
K
T
I
A
K
R
Site 44
T511
S
L
P
V
D
D
T
T
K
T
I
A
K
R
L
Site 45
T513
P
V
D
D
T
T
K
T
I
A
K
R
L
E
A
Site 46
Y521
I
A
K
R
L
E
A
Y
Y
R
A
S
I
P
V
Site 47
Y522
A
K
R
L
E
A
Y
Y
R
A
S
I
P
V
I
Site 48
Y532
S
I
P
V
I
A
Y
Y
E
T
K
T
Q
L
H
Site 49
T546
H
K
I
N
A
E
G
T
P
E
D
V
F
L
Q
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation