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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
TLL2
Full Name:
Tolloid-like protein 2
Alias:
EC 3.4.24.-; Tolloid-like 2; Tolloid-like protein 2
Type:
Extracellular region protein
Mass (Da):
113557
Number AA:
1015
UniProt ID:
Q9Y6L7
International Prot ID:
IPI00465231
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005576
Uniprot
OncoNet
Molecular Function:
GO:0005509
GO:0004222
GO:0008270
PhosphoSite+
KinaseNET
Biological Process:
GO:0030154
GO:0007275
GO:0006508
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T33
L
G
E
R
P
D
A
T
A
D
Y
S
E
L
D
Site 2
Y36
R
P
D
A
T
A
D
Y
S
E
L
D
G
E
E
Site 3
S37
P
D
A
T
A
D
Y
S
E
L
D
G
E
E
G
Site 4
Y52
T
E
Q
Q
L
E
H
Y
H
D
P
C
K
A
A
Site 5
T84
I
D
K
A
R
D
W
T
K
Q
T
V
G
A
T
Site 6
T87
A
R
D
W
T
K
Q
T
V
G
A
T
G
H
S
Site 7
S103
G
G
L
E
E
Q
A
S
E
S
S
P
D
T
T
Site 8
S105
L
E
E
Q
A
S
E
S
S
P
D
T
T
A
M
Site 9
S106
E
E
Q
A
S
E
S
S
P
D
T
T
A
M
D
Site 10
T109
A
S
E
S
S
P
D
T
T
A
M
D
T
G
T
Site 11
T110
S
E
S
S
P
D
T
T
A
M
D
T
G
T
K
Site 12
T116
T
T
A
M
D
T
G
T
K
E
A
G
K
D
G
Site 13
T127
G
K
D
G
R
E
N
T
T
L
L
H
S
P
G
Site 14
T128
K
D
G
R
E
N
T
T
L
L
H
S
P
G
T
Site 15
S132
E
N
T
T
L
L
H
S
P
G
T
L
H
A
A
Site 16
T142
T
L
H
A
A
A
K
T
F
S
P
R
V
R
R
Site 17
S144
H
A
A
A
K
T
F
S
P
R
V
R
R
A
T
Site 18
T151
S
P
R
V
R
R
A
T
T
S
R
T
E
R
I
Site 19
T152
P
R
V
R
R
A
T
T
S
R
T
E
R
I
W
Site 20
S153
R
V
R
R
A
T
T
S
R
T
E
R
I
W
P
Site 21
T155
R
R
A
T
T
S
R
T
E
R
I
W
P
G
G
Site 22
S175
I
G
G
N
F
T
G
S
Q
R
A
I
F
K
Q
Site 23
S203
I
E
R
T
D
E
E
S
F
I
V
F
S
Y
R
Site 24
Y217
R
T
C
G
C
C
S
Y
V
G
R
R
G
G
G
Site 25
S229
G
G
G
P
Q
A
I
S
I
G
K
N
C
D
K
Site 26
T264
P
D
R
D
Q
H
V
T
I
I
R
E
N
I
Q
Site 27
T292
E
V
S
S
L
G
E
T
Y
D
F
D
S
I
M
Site 28
Y293
V
S
S
L
G
E
T
Y
D
F
D
S
I
M
H
Site 29
Y301
D
F
D
S
I
M
H
Y
A
R
N
T
F
S
R
Site 30
T314
S
R
G
V
F
L
D
T
I
L
P
R
Q
D
D
Site 31
T327
D
D
N
G
V
R
P
T
I
G
Q
R
V
R
L
Site 32
S335
I
G
Q
R
V
R
L
S
Q
G
D
I
A
Q
A
Site 33
Y346
I
A
Q
A
R
K
L
Y
K
C
P
A
C
G
E
Site 34
T358
C
G
E
T
L
Q
D
T
T
G
N
F
S
A
P
Site 35
T359
G
E
T
L
Q
D
T
T
G
N
F
S
A
P
G
Site 36
S363
Q
D
T
T
G
N
F
S
A
P
G
F
P
N
G
Site 37
Y371
A
P
G
F
P
N
G
Y
P
S
Y
S
H
C
V
Site 38
T384
C
V
W
R
I
S
V
T
P
G
E
K
I
V
L
Site 39
Y406
F
K
S
R
L
C
W
Y
D
Y
V
E
V
R
D
Site 40
Y408
S
R
L
C
W
Y
D
Y
V
E
V
R
D
G
Y
Site 41
Y415
Y
V
E
V
R
D
G
Y
W
R
K
A
P
L
L
Site 42
S436
K
I
P
E
P
L
V
S
T
D
S
R
L
W
V
Site 43
S439
E
P
L
V
S
T
D
S
R
L
W
V
E
F
R
Site 44
S447
R
L
W
V
E
F
R
S
S
S
N
I
L
G
K
Site 45
S448
L
W
V
E
F
R
S
S
S
N
I
L
G
K
G
Site 46
S449
W
V
E
F
R
S
S
S
N
I
L
G
K
G
F
Site 47
Y460
G
K
G
F
F
A
A
Y
E
A
T
C
G
G
D
Site 48
S477
K
D
A
G
Q
I
Q
S
P
N
Y
P
D
D
Y
Site 49
Y480
G
Q
I
Q
S
P
N
Y
P
D
D
Y
R
P
S
Site 50
Y484
S
P
N
Y
P
D
D
Y
R
P
S
K
E
C
V
Site 51
Y521
H
D
S
C
A
Y
D
Y
L
E
V
R
D
G
P
Site 52
T529
L
E
V
R
D
G
P
T
E
E
S
A
L
I
G
Site 53
Y541
L
I
G
H
F
C
G
Y
E
K
P
E
D
V
K
Site 54
S549
E
K
P
E
D
V
K
S
S
S
N
R
L
W
M
Site 55
S550
K
P
E
D
V
K
S
S
S
N
R
L
W
M
K
Site 56
S551
P
E
D
V
K
S
S
S
N
R
L
W
M
K
F
Site 57
Y607
K
C
A
C
D
P
G
Y
E
L
A
A
D
K
K
Site 58
T632
T
K
L
N
G
T
I
T
S
P
G
W
P
K
E
Site 59
S633
K
L
N
G
T
I
T
S
P
G
W
P
K
E
Y
Site 60
Y640
S
P
G
W
P
K
E
Y
P
T
N
K
N
C
V
Site 61
S659
A
P
A
Q
Y
R
I
S
L
Q
F
E
V
F
E
Site 62
Y675
E
G
N
D
V
C
K
Y
D
F
V
E
V
R
S
Site 63
S685
V
E
V
R
S
G
L
S
P
D
A
K
L
H
G
Site 64
T699
G
R
F
C
G
S
E
T
P
E
V
I
T
S
Q
Site 65
S705
E
T
P
E
V
I
T
S
Q
S
N
N
M
R
V
Site 66
S716
N
M
R
V
E
F
K
S
D
N
T
V
S
K
R
Site 67
T719
V
E
F
K
S
D
N
T
V
S
K
R
G
F
R
Site 68
S721
F
K
S
D
N
T
V
S
K
R
G
F
R
A
H
Site 69
S731
G
F
R
A
H
F
F
S
D
K
D
E
C
A
K
Site 70
Y754
C
V
N
T
F
G
S
Y
L
C
R
C
R
N
G
Site 71
T786
K
I
S
S
V
E
G
T
L
A
S
P
N
W
P
Site 72
S789
S
V
E
G
T
L
A
S
P
N
W
P
D
K
Y
Site 73
Y796
S
P
N
W
P
D
K
Y
P
S
R
R
E
C
T
Site 74
T803
Y
P
S
R
R
E
C
T
W
N
I
S
S
T
A
Site 75
T817
A
G
H
R
V
K
L
T
F
N
E
F
E
I
E
Site 76
Y831
E
Q
H
Q
E
C
A
Y
D
H
L
E
M
Y
D
Site 77
Y837
A
Y
D
H
L
E
M
Y
D
G
P
D
S
L
A
Site 78
S842
E
M
Y
D
G
P
D
S
L
A
P
I
L
G
R
Site 79
T859
G
S
K
K
P
D
P
T
V
A
S
G
S
S
M
Site 80
S862
K
P
D
P
T
V
A
S
G
S
S
M
F
L
R
Site 81
S864
D
P
T
V
A
S
G
S
S
M
F
L
R
F
Y
Site 82
Y871
S
S
M
F
L
R
F
Y
S
D
A
S
V
Q
R
Site 83
S872
S
M
F
L
R
F
Y
S
D
A
S
V
Q
R
K
Site 84
S875
L
R
F
Y
S
D
A
S
V
Q
R
K
G
F
Q
Site 85
S886
K
G
F
Q
A
V
H
S
T
E
C
G
G
R
L
Site 86
T899
R
L
K
A
E
V
Q
T
K
E
L
Y
S
H
A
Site 87
Y903
E
V
Q
T
K
E
L
Y
S
H
A
Q
F
G
D
Site 88
S904
V
Q
T
K
E
L
Y
S
H
A
Q
F
G
D
N
Site 89
Y913
A
Q
F
G
D
N
N
Y
P
S
E
A
R
C
D
Site 90
T934
D
G
Y
G
V
E
L
T
F
R
T
F
E
V
E
Site 91
T937
G
V
E
L
T
F
R
T
F
E
V
E
E
E
A
Site 92
Y948
E
E
E
A
D
C
G
Y
D
Y
M
E
A
Y
D
Site 93
Y950
E
A
D
C
G
Y
D
Y
M
E
A
Y
D
G
Y
Site 94
Y954
G
Y
D
Y
M
E
A
Y
D
G
Y
D
S
S
A
Site 95
Y957
Y
M
E
A
Y
D
G
Y
D
S
S
A
P
R
L
Site 96
S959
E
A
Y
D
G
Y
D
S
S
A
P
R
L
G
R
Site 97
S960
A
Y
D
G
Y
D
S
S
A
P
R
L
G
R
F
Site 98
Y977
S
G
P
L
E
E
I
Y
S
A
G
D
S
L
M
Site 99
S982
E
I
Y
S
A
G
D
S
L
M
I
R
F
R
T
Site 100
T989
S
L
M
I
R
F
R
T
D
D
T
I
N
K
K
Site 101
T992
I
R
F
R
T
D
D
T
I
N
K
K
G
F
H
Site 102
Y1002
K
K
G
F
H
A
R
Y
T
S
T
K
F
Q
D
Site 103
T1003
K
G
F
H
A
R
Y
T
S
T
K
F
Q
D
A
Site 104
S1004
G
F
H
A
R
Y
T
S
T
K
F
Q
D
A
L
Site 105
T1005
F
H
A
R
Y
T
S
T
K
F
Q
D
A
L
H
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation