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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
ROBO1
Full Name:
Roundabout homolog 1
Alias:
Axon guidance receptor; Deleted in U twenty twenty; DUTT1; FLJ21882; H-Robo-1; Roundabout 1; Roundabout homolog 1 precursor; Roundabout, axon guidance receptor, 1; Roundabout, axon guidance receptor, homolog 1 (Drosophila); SAX3
Type:
Adhesion protein
Mass (Da):
180930
Number AA:
1651
UniProt ID:
Q9Y6N7
International Prot ID:
IPI00219798
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0009986
GO:0005887
GO:0016020
Uniprot
OncoNet
Molecular Function:
GO:0008046
GO:0042802
GO:0004888
PhosphoSite+
KinaseNET
Biological Process:
GO:0002042
GO:0006935
GO:0007156
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y102
P
T
P
T
I
E
W
Y
K
G
G
E
R
V
E
Site 2
S251
N
M
V
G
E
R
E
S
E
V
A
E
L
T
V
Site 3
S305
D
D
G
E
L
P
K
S
R
Y
E
I
R
D
D
Site 4
T321
T
L
K
I
R
K
V
T
A
G
D
M
G
S
Y
Site 5
Y328
T
A
G
D
M
G
S
Y
T
C
V
A
E
N
M
Site 6
S855
Y
S
V
E
V
A
A
S
T
G
A
G
S
G
V
Site 7
Y919
M
V
F
S
I
W
L
Y
R
H
R
K
K
R
N
Site 8
S930
K
K
R
N
G
L
T
S
T
Y
A
G
I
R
K
Site 9
Y932
R
N
G
L
T
S
T
Y
A
G
I
R
K
V
P
Site 10
S940
A
G
I
R
K
V
P
S
F
T
F
T
P
T
V
Site 11
T942
I
R
K
V
P
S
F
T
F
T
P
T
V
T
Y
Site 12
T944
K
V
P
S
F
T
F
T
P
T
V
T
Y
Q
R
Site 13
T946
P
S
F
T
F
T
P
T
V
T
Y
Q
R
G
G
Site 14
Y949
T
F
T
P
T
V
T
Y
Q
R
G
G
E
A
V
Site 15
S957
Q
R
G
G
E
A
V
S
S
G
G
R
P
G
L
Site 16
S958
R
G
G
E
A
V
S
S
G
G
R
P
G
L
L
Site 17
S968
R
P
G
L
L
N
I
S
E
P
A
A
Q
P
W
Site 18
S1002
C
T
A
G
N
G
N
S
D
S
N
L
T
T
Y
Site 19
S1004
A
G
N
G
N
S
D
S
N
L
T
T
Y
S
R
Site 20
T1007
G
N
S
D
S
N
L
T
T
Y
S
R
P
A
D
Site 21
T1008
N
S
D
S
N
L
T
T
Y
S
R
P
A
D
C
Site 22
Y1009
S
D
S
N
L
T
T
Y
S
R
P
A
D
C
I
Site 23
Y1019
P
A
D
C
I
A
N
Y
N
N
Q
L
D
N
K
Site 24
S1035
T
N
L
M
L
P
E
S
T
V
Y
G
D
V
D
Site 25
Y1038
M
L
P
E
S
T
V
Y
G
D
V
D
L
S
N
Site 26
T1052
N
K
I
N
E
M
K
T
F
N
S
P
N
L
K
Site 27
S1055
N
E
M
K
T
F
N
S
P
N
L
K
D
G
R
Site 28
S1067
D
G
R
F
V
N
P
S
G
Q
P
T
P
Y
A
Site 29
T1071
V
N
P
S
G
Q
P
T
P
Y
A
T
T
Q
L
Site 30
Y1073
P
S
G
Q
P
T
P
Y
A
T
T
Q
L
I
Q
Site 31
S1084
Q
L
I
Q
S
N
L
S
N
N
M
N
N
G
S
Site 32
Y1114
Q
E
V
A
P
V
Q
Y
N
I
V
E
Q
N
K
Site 33
Y1126
Q
N
K
L
N
K
D
Y
R
A
N
D
T
V
P
Site 34
T1131
K
D
Y
R
A
N
D
T
V
P
P
T
I
P
Y
Site 35
T1135
A
N
D
T
V
P
P
T
I
P
Y
N
Q
S
Y
Site 36
S1141
P
T
I
P
Y
N
Q
S
Y
D
Q
N
T
G
G
Site 37
Y1142
T
I
P
Y
N
Q
S
Y
D
Q
N
T
G
G
S
Site 38
S1149
Y
D
Q
N
T
G
G
S
Y
N
S
S
D
R
G
Site 39
S1152
N
T
G
G
S
Y
N
S
S
D
R
G
S
S
T
Site 40
S1153
T
G
G
S
Y
N
S
S
D
R
G
S
S
T
S
Site 41
S1157
Y
N
S
S
D
R
G
S
S
T
S
G
S
Q
G
Site 42
S1158
N
S
S
D
R
G
S
S
T
S
G
S
Q
G
H
Site 43
T1159
S
S
D
R
G
S
S
T
S
G
S
Q
G
H
K
Site 44
S1160
S
D
R
G
S
S
T
S
G
S
Q
G
H
K
K
Site 45
S1162
R
G
S
S
T
S
G
S
Q
G
H
K
K
G
A
Site 46
T1171
G
H
K
K
G
A
R
T
P
K
V
P
K
Q
G
Site 47
S1197
P
A
H
P
P
P
H
S
N
S
E
E
Y
N
I
Site 48
S1199
H
P
P
P
H
S
N
S
E
E
Y
N
I
S
V
Site 49
S1205
N
S
E
E
Y
N
I
S
V
D
E
S
Y
D
Q
Site 50
Y1210
N
I
S
V
D
E
S
Y
D
Q
E
M
P
C
P
Site 51
Y1224
P
V
P
P
A
R
M
Y
L
Q
Q
D
E
L
E
Site 52
T1240
E
E
D
E
R
G
P
T
P
P
V
R
G
A
A
Site 53
S1248
P
P
V
R
G
A
A
S
S
P
A
A
V
S
Y
Site 54
S1249
P
V
R
G
A
A
S
S
P
A
A
V
S
Y
S
Site 55
S1254
A
S
S
P
A
A
V
S
Y
S
H
Q
S
T
A
Site 56
Y1255
S
S
P
A
A
V
S
Y
S
H
Q
S
T
A
T
Site 57
T1260
V
S
Y
S
H
Q
S
T
A
T
L
T
P
S
P
Site 58
T1262
Y
S
H
Q
S
T
A
T
L
T
P
S
P
Q
E
Site 59
T1264
H
Q
S
T
A
T
L
T
P
S
P
Q
E
E
L
Site 60
S1266
S
T
A
T
L
T
P
S
P
Q
E
E
L
Q
P
Site 61
S1297
D
R
R
R
Q
P
V
S
P
P
P
P
P
R
P
Site 62
S1306
P
P
P
P
R
P
I
S
P
P
H
T
Y
G
Y
Site 63
T1310
R
P
I
S
P
P
H
T
Y
G
Y
I
S
G
P
Site 64
Y1311
P
I
S
P
P
H
T
Y
G
Y
I
S
G
P
L
Site 65
Y1313
S
P
P
H
T
Y
G
Y
I
S
G
P
L
V
S
Site 66
S1320
Y
I
S
G
P
L
V
S
D
M
D
T
D
A
P
Site 67
T1324
P
L
V
S
D
M
D
T
D
A
P
E
E
E
E
Site 68
T1354
L
L
R
G
L
E
Q
T
P
A
S
S
V
G
D
Site 69
S1357
G
L
E
Q
T
P
A
S
S
V
G
D
L
E
S
Site 70
S1358
L
E
Q
T
P
A
S
S
V
G
D
L
E
S
S
Site 71
S1365
S
V
G
D
L
E
S
S
V
T
G
S
M
I
N
Site 72
T1367
G
D
L
E
S
S
V
T
G
S
M
I
N
G
W
Site 73
S1369
L
E
S
S
V
T
G
S
M
I
N
G
W
G
S
Site 74
S1376
S
M
I
N
G
W
G
S
A
S
E
E
D
N
I
Site 75
S1378
I
N
G
W
G
S
A
S
E
E
D
N
I
S
S
Site 76
S1384
A
S
E
E
D
N
I
S
S
G
R
S
S
V
S
Site 77
S1385
S
E
E
D
N
I
S
S
G
R
S
S
V
S
S
Site 78
S1388
D
N
I
S
S
G
R
S
S
V
S
S
S
D
G
Site 79
S1389
N
I
S
S
G
R
S
S
V
S
S
S
D
G
S
Site 80
S1391
S
S
G
R
S
S
V
S
S
S
D
G
S
F
F
Site 81
S1392
S
G
R
S
S
V
S
S
S
D
G
S
F
F
T
Site 82
S1393
G
R
S
S
V
S
S
S
D
G
S
F
F
T
D
Site 83
S1396
S
V
S
S
S
D
G
S
F
F
T
D
A
D
F
Site 84
Y1413
A
V
A
A
A
A
E
Y
A
G
L
K
V
A
R
Site 85
S1435
G
R
R
H
F
H
A
S
Q
C
P
R
P
T
S
Site 86
T1441
A
S
Q
C
P
R
P
T
S
P
V
S
T
D
S
Site 87
S1442
S
Q
C
P
R
P
T
S
P
V
S
T
D
S
N
Site 88
S1445
P
R
P
T
S
P
V
S
T
D
S
N
M
S
A
Site 89
T1446
R
P
T
S
P
V
S
T
D
S
N
M
S
A
A
Site 90
S1448
T
S
P
V
S
T
D
S
N
M
S
A
A
V
M
Site 91
T1475
P
G
H
L
R
R
E
T
Y
T
D
D
L
P
P
Site 92
Y1476
G
H
L
R
R
E
T
Y
T
D
D
L
P
P
P
Site 93
T1477
H
L
R
R
E
T
Y
T
D
D
L
P
P
P
P
Site 94
S1492
V
P
P
P
A
I
K
S
P
T
A
Q
S
K
T
Site 95
T1494
P
P
A
I
K
S
P
T
A
Q
S
K
T
Q
L
Site 96
T1518
L
P
S
M
D
A
R
T
D
R
S
S
D
R
K
Site 97
S1521
M
D
A
R
T
D
R
S
S
D
R
K
G
S
S
Site 98
S1522
D
A
R
T
D
R
S
S
D
R
K
G
S
S
Y
Site 99
S1527
R
S
S
D
R
K
G
S
S
Y
K
G
R
E
V
Site 100
S1528
S
S
D
R
K
G
S
S
Y
K
G
R
E
V
L
Site 101
Y1529
S
D
R
K
G
S
S
Y
K
G
R
E
V
L
D
Site 102
T1545
R
Q
V
V
D
M
R
T
N
P
G
D
P
R
E
Site 103
T1577
R
D
L
P
P
A
K
T
H
L
I
Q
E
D
I
Site 104
Y1587
I
Q
E
D
I
L
P
Y
C
R
P
T
F
P
T
Site 105
T1591
I
L
P
Y
C
R
P
T
F
P
T
S
N
N
P
Site 106
S1595
C
R
P
T
F
P
T
S
N
N
P
R
D
P
S
Site 107
S1602
S
N
N
P
R
D
P
S
S
S
S
S
M
S
S
Site 108
S1603
N
N
P
R
D
P
S
S
S
S
S
M
S
S
R
Site 109
S1604
N
P
R
D
P
S
S
S
S
S
M
S
S
R
G
Site 110
S1605
P
R
D
P
S
S
S
S
S
M
S
S
R
G
S
Site 111
S1606
R
D
P
S
S
S
S
S
M
S
S
R
G
S
G
Site 112
S1608
P
S
S
S
S
S
M
S
S
R
G
S
G
S
R
Site 113
S1609
S
S
S
S
S
M
S
S
R
G
S
G
S
R
Q
Site 114
S1612
S
S
M
S
S
R
G
S
G
S
R
Q
R
E
Q
Site 115
Y1636
E
M
Q
V
L
G
G
Y
E
R
G
E
D
N
N
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation