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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
SESN1
Full Name:
Sestrin-1
Alias:
MGC138241; MGC142129; PA26; SEST1
Type:
Mass (Da):
56557
Number AA:
492
UniProt ID:
Q9Y6P5
International Prot ID:
IPI00002536
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005634
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
GO:0007050
GO:0008285
GO:0006974
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T101
Y
L
E
S
F
L
K
T
Q
H
Y
L
L
Q
M
Site 2
Y104
S
F
L
K
T
Q
H
Y
L
L
Q
M
D
G
P
Site 3
Y116
D
G
P
L
P
L
H
Y
R
H
Y
I
G
I
M
Site 4
Y132
A
A
R
H
Q
C
S
Y
L
V
N
L
H
V
N
Site 5
T179
A
H
R
P
W
L
I
T
K
E
H
I
E
G
L
Site 6
S195
K
A
E
E
H
S
W
S
L
A
E
L
V
H
A
Site 7
T232
I
H
C
D
G
G
H
T
F
R
P
P
S
V
S
Site 8
Y241
R
P
P
S
V
S
N
Y
C
I
C
D
I
T
N
Site 9
S252
D
I
T
N
G
N
H
S
V
D
E
M
P
V
N
Site 10
S265
V
N
S
A
E
N
V
S
V
S
D
S
F
F
E
Site 11
S267
S
A
E
N
V
S
V
S
D
S
F
F
E
V
E
Site 12
S293
C
R
D
E
E
E
A
S
Q
E
E
M
A
S
R
Site 13
S299
A
S
Q
E
E
M
A
S
R
F
E
I
E
K
R
Site 14
S308
F
E
I
E
K
R
E
S
M
F
V
F
S
S
D
Site 15
S314
E
S
M
F
V
F
S
S
D
D
E
E
V
T
P
Site 16
T320
S
S
D
D
E
E
V
T
P
A
R
A
V
S
R
Site 17
S326
V
T
P
A
R
A
V
S
R
H
F
E
D
T
S
Site 18
T332
V
S
R
H
F
E
D
T
S
Y
G
Y
K
D
F
Site 19
S333
S
R
H
F
E
D
T
S
Y
G
Y
K
D
F
S
Site 20
Y334
R
H
F
E
D
T
S
Y
G
Y
K
D
F
S
R
Site 21
Y336
F
E
D
T
S
Y
G
Y
K
D
F
S
R
H
G
Site 22
Y361
Y
C
W
E
D
H
G
Y
S
L
V
N
R
L
Y
Site 23
T398
A
M
H
K
D
V
D
T
S
M
L
R
R
A
I
Site 24
Y417
H
C
M
F
G
I
R
Y
D
D
Y
D
Y
G
E
Site 25
Y420
F
G
I
R
Y
D
D
Y
D
Y
G
E
I
N
Q
Site 26
Y422
I
R
Y
D
D
Y
D
Y
G
E
I
N
Q
L
L
Site 27
S432
I
N
Q
L
L
D
R
S
F
K
V
Y
I
K
T
Site 28
T443
Y
I
K
T
V
V
C
T
P
E
K
V
T
K
R
Site 29
Y452
E
K
V
T
K
R
M
Y
D
S
F
W
R
Q
F
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation