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Updated November 2019
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Protein Info
Short Name:
NCOA3
Full Name:
Nuclear receptor coactivator 3
Alias:
ACTR; AIB1; AIB-1; Amplified in breast cancer-1 protein; BHLHe42; CAGH16; CBP-interacting protein; KAT13B; NCO3; NCoA-3; P/CIP; PCIP; RAC3; RAC-3; Receptor-associated coactivator 3; SRC3; SRC-3; Steroid receptor coactivator protein 3; Thyroid hormone receptor activator molecule 1; TNRC16; TRAM1; TRAM-1
Type:
EC 2.3.1.48; Acetyltransferase; Transcription, coactivator/corepressor; Nuclear receptor co-regulator
Mass (Da):
155293
Number AA:
1424
UniProt ID:
Q9Y6Q9
International Prot ID:
IPI00069270
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0050681
GO:0004402
GO:0047485
PhosphoSite+
KinaseNET
Biological Process:
GO:0030521
GO:0045893
GO:0006350
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S13
E
N
L
D
P
L
A
S
D
S
R
K
R
K
L
Site 2
S15
L
D
P
L
A
S
D
S
R
K
R
K
L
P
C
Site 3
T24
K
R
K
L
P
C
D
T
P
G
Q
G
L
T
C
Site 4
T30
D
T
P
G
Q
G
L
T
C
S
G
E
K
R
R
Site 5
S32
P
G
Q
G
L
T
C
S
G
E
K
R
R
R
E
Site 6
S42
K
R
R
R
E
Q
E
S
K
Y
I
E
E
L
A
Site 7
Y44
R
R
E
Q
E
S
K
Y
I
E
E
L
A
E
L
Site 8
S53
E
E
L
A
E
L
I
S
A
N
L
S
D
I
D
Site 9
T75
K
C
A
I
L
K
E
T
V
R
Q
I
R
Q
I
Site 10
T88
Q
I
K
E
Q
G
K
T
I
S
N
D
D
D
V
Site 11
S90
K
E
Q
G
K
T
I
S
N
D
D
D
V
Q
K
Site 12
S101
D
V
Q
K
A
D
V
S
S
T
G
Q
G
V
I
Site 13
S102
V
Q
K
A
D
V
S
S
T
G
Q
G
V
I
D
Site 14
T142
V
F
V
S
E
N
V
T
Q
Y
L
Q
Y
K
Q
Site 15
Y144
V
S
E
N
V
T
Q
Y
L
Q
Y
K
Q
E
D
Site 16
S156
Q
E
D
L
V
N
T
S
V
Y
N
I
L
H
E
Site 17
S176
F
L
K
N
L
P
K
S
T
V
N
G
V
S
W
Site 18
T177
L
K
N
L
P
K
S
T
V
N
G
V
S
W
T
Site 19
T184
T
V
N
G
V
S
W
T
N
E
T
Q
R
Q
K
Site 20
T187
G
V
S
W
T
N
E
T
Q
R
Q
K
S
H
T
Site 21
T194
T
Q
R
Q
K
S
H
T
F
N
C
R
M
L
M
Site 22
T203
N
C
R
M
L
M
K
T
P
H
D
I
L
E
D
Site 23
S214
I
L
E
D
I
N
A
S
P
E
M
R
Q
R
Y
Site 24
Y221
S
P
E
M
R
Q
R
Y
E
T
M
Q
C
F
A
Site 25
T223
E
M
R
Q
R
Y
E
T
M
Q
C
F
A
L
S
Site 26
S244
E
E
G
E
D
L
Q
S
C
M
I
C
V
A
R
Site 27
T254
I
C
V
A
R
R
I
T
T
G
E
R
T
F
P
Site 28
T255
C
V
A
R
R
I
T
T
G
E
R
T
F
P
S
Site 29
T259
R
I
T
T
G
E
R
T
F
P
S
N
P
E
S
Site 30
S262
T
G
E
R
T
F
P
S
N
P
E
S
F
I
T
Site 31
S266
T
F
P
S
N
P
E
S
F
I
T
R
H
D
L
Site 32
T269
S
N
P
E
S
F
I
T
R
H
D
L
S
G
K
Site 33
S274
F
I
T
R
H
D
L
S
G
K
V
V
N
I
D
Site 34
T282
G
K
V
V
N
I
D
T
N
S
L
R
S
S
M
Site 35
S284
V
V
N
I
D
T
N
S
L
R
S
S
M
R
P
Site 36
S287
I
D
T
N
S
L
R
S
S
M
R
P
G
F
E
Site 37
S288
D
T
N
S
L
R
S
S
M
R
P
G
F
E
D
Site 38
S312
F
S
L
N
D
G
Q
S
W
S
Q
K
R
H
Y
Site 39
Y319
S
W
S
Q
K
R
H
Y
Q
E
A
Y
L
N
G
Site 40
T330
Y
L
N
G
H
A
E
T
P
V
Y
R
F
S
L
Site 41
Y333
G
H
A
E
T
P
V
Y
R
F
S
L
A
D
G
Site 42
T341
R
F
S
L
A
D
G
T
I
V
T
A
Q
T
K
Site 43
S349
I
V
T
A
Q
T
K
S
K
L
F
R
N
P
V
Site 44
T357
K
L
F
R
N
P
V
T
N
D
R
H
G
F
V
Site 45
S365
N
D
R
H
G
F
V
S
T
H
F
L
Q
R
E
Site 46
Y376
L
Q
R
E
Q
N
G
Y
R
P
N
P
N
P
V
Site 47
S402
N
S
S
V
G
G
M
S
M
S
P
N
Q
G
L
Site 48
S404
S
V
G
G
M
S
M
S
P
N
Q
G
L
Q
M
Site 49
S413
N
Q
G
L
Q
M
P
S
S
R
A
Y
G
L
A
Site 50
S414
Q
G
L
Q
M
P
S
S
R
A
Y
G
L
A
D
Site 51
Y417
Q
M
P
S
S
R
A
Y
G
L
A
D
P
S
T
Site 52
S423
A
Y
G
L
A
D
P
S
T
T
G
Q
M
S
G
Site 53
T424
Y
G
L
A
D
P
S
T
T
G
Q
M
S
G
A
Site 54
S429
P
S
T
T
G
Q
M
S
G
A
R
Y
G
G
S
Site 55
Y433
G
Q
M
S
G
A
R
Y
G
G
S
S
N
I
A
Site 56
S436
S
G
A
R
Y
G
G
S
S
N
I
A
S
L
T
Site 57
S437
G
A
R
Y
G
G
S
S
N
I
A
S
L
T
P
Site 58
S441
G
G
S
S
N
I
A
S
L
T
P
G
P
G
M
Site 59
T443
S
S
N
I
A
S
L
T
P
G
P
G
M
Q
S
Site 60
S450
T
P
G
P
G
M
Q
S
P
S
S
Y
Q
N
N
Site 61
S452
G
P
G
M
Q
S
P
S
S
Y
Q
N
N
N
Y
Site 62
S453
P
G
M
Q
S
P
S
S
Y
Q
N
N
N
Y
G
Site 63
Y454
G
M
Q
S
P
S
S
Y
Q
N
N
N
Y
G
L
Site 64
Y459
S
S
Y
Q
N
N
N
Y
G
L
N
M
S
S
P
Site 65
S464
N
N
Y
G
L
N
M
S
S
P
P
H
G
S
P
Site 66
S465
N
Y
G
L
N
M
S
S
P
P
H
G
S
P
G
Site 67
S470
M
S
S
P
P
H
G
S
P
G
L
A
P
N
Q
Site 68
S483
N
Q
Q
N
I
M
I
S
P
R
N
R
G
S
P
Site 69
S489
I
S
P
R
N
R
G
S
P
K
I
A
S
H
Q
Site 70
S494
R
G
S
P
K
I
A
S
H
Q
F
S
P
V
A
Site 71
S498
K
I
A
S
H
Q
F
S
P
V
A
G
V
H
S
Site 72
S505
S
P
V
A
G
V
H
S
P
M
A
S
S
G
N
Site 73
S509
G
V
H
S
P
M
A
S
S
G
N
T
G
N
H
Site 74
T513
P
M
A
S
S
G
N
T
G
N
H
S
F
S
S
Site 75
S517
S
G
N
T
G
N
H
S
F
S
S
S
S
L
S
Site 76
S519
N
T
G
N
H
S
F
S
S
S
S
L
S
A
L
Site 77
S520
T
G
N
H
S
F
S
S
S
S
L
S
A
L
Q
Site 78
S521
G
N
H
S
F
S
S
S
S
L
S
A
L
Q
A
Site 79
S522
N
H
S
F
S
S
S
S
L
S
A
L
Q
A
I
Site 80
S524
S
F
S
S
S
S
L
S
A
L
Q
A
I
S
E
Site 81
T540
V
G
T
S
L
L
S
T
L
S
S
P
G
P
K
Site 82
S542
T
S
L
L
S
T
L
S
S
P
G
P
K
L
D
Site 83
S543
S
L
L
S
T
L
S
S
P
G
P
K
L
D
N
Site 84
S551
P
G
P
K
L
D
N
S
P
N
M
N
I
T
Q
Site 85
T557
N
S
P
N
M
N
I
T
Q
P
S
K
V
S
N
Site 86
S563
I
T
Q
P
S
K
V
S
N
Q
D
S
K
S
P
Site 87
S567
S
K
V
S
N
Q
D
S
K
S
P
L
G
F
Y
Site 88
S569
V
S
N
Q
D
S
K
S
P
L
G
F
Y
C
D
Site 89
Y574
S
K
S
P
L
G
F
Y
C
D
Q
N
P
V
E
Site 90
S583
D
Q
N
P
V
E
S
S
M
C
Q
S
N
S
R
Site 91
S587
V
E
S
S
M
C
Q
S
N
S
R
D
H
L
S
Site 92
S589
S
S
M
C
Q
S
N
S
R
D
H
L
S
D
K
Site 93
S594
S
N
S
R
D
H
L
S
D
K
E
S
K
E
S
Site 94
S598
D
H
L
S
D
K
E
S
K
E
S
S
V
E
G
Site 95
S601
S
D
K
E
S
K
E
S
S
V
E
G
A
E
N
Site 96
S602
D
K
E
S
K
E
S
S
V
E
G
A
E
N
Q
Site 97
S615
N
Q
R
G
P
L
E
S
K
G
H
K
K
L
L
Site 98
T626
K
K
L
L
Q
L
L
T
C
S
S
D
D
R
G
Site 99
S628
L
L
Q
L
L
T
C
S
S
D
D
R
G
H
S
Site 100
S629
L
Q
L
L
T
C
S
S
D
D
R
G
H
S
S
Site 101
S635
S
S
D
D
R
G
H
S
S
L
T
N
S
P
L
Site 102
S636
S
D
D
R
G
H
S
S
L
T
N
S
P
L
D
Site 103
T638
D
R
G
H
S
S
L
T
N
S
P
L
D
S
S
Site 104
S640
G
H
S
S
L
T
N
S
P
L
D
S
S
C
K
Site 105
S644
L
T
N
S
P
L
D
S
S
C
K
E
S
S
V
Site 106
S645
T
N
S
P
L
D
S
S
C
K
E
S
S
V
S
Site 107
S649
L
D
S
S
C
K
E
S
S
V
S
V
T
S
P
Site 108
S650
D
S
S
C
K
E
S
S
V
S
V
T
S
P
S
Site 109
S652
S
C
K
E
S
S
V
S
V
T
S
P
S
G
V
Site 110
T654
K
E
S
S
V
S
V
T
S
P
S
G
V
S
S
Site 111
S655
E
S
S
V
S
V
T
S
P
S
G
V
S
S
S
Site 112
S657
S
V
S
V
T
S
P
S
G
V
S
S
S
T
S
Site 113
S660
V
T
S
P
S
G
V
S
S
S
T
S
G
G
V
Site 114
S661
T
S
P
S
G
V
S
S
S
T
S
G
G
V
S
Site 115
S662
S
P
S
G
V
S
S
S
T
S
G
G
V
S
S
Site 116
S664
S
G
V
S
S
S
T
S
G
G
V
S
S
T
S
Site 117
S668
S
S
T
S
G
G
V
S
S
T
S
N
M
H
G
Site 118
S669
S
T
S
G
G
V
S
S
T
S
N
M
H
G
S
Site 119
S671
S
G
G
V
S
S
T
S
N
M
H
G
S
L
L
Site 120
S676
S
T
S
N
M
H
G
S
L
L
Q
E
K
H
R
Site 121
S694
K
L
L
Q
N
G
N
S
P
A
E
V
A
K
I
Site 122
T710
A
E
A
T
G
K
D
T
S
S
I
T
S
C
G
Site 123
S711
E
A
T
G
K
D
T
S
S
I
T
S
C
G
D
Site 124
S712
A
T
G
K
D
T
S
S
I
T
S
C
G
D
G
Site 125
S715
K
D
T
S
S
I
T
S
C
G
D
G
N
V
V
Site 126
S728
V
V
K
Q
E
Q
L
S
P
K
K
K
E
N
N
Site 127
S748
L
L
D
R
D
D
P
S
D
A
L
S
K
E
L
Site 128
S752
D
D
P
S
D
A
L
S
K
E
L
Q
P
Q
V
Site 129
S767
E
G
V
D
N
K
M
S
Q
C
T
S
S
T
I
Site 130
S771
N
K
M
S
Q
C
T
S
S
T
I
P
S
S
S
Site 131
S772
K
M
S
Q
C
T
S
S
T
I
P
S
S
S
Q
Site 132
T773
M
S
Q
C
T
S
S
T
I
P
S
S
S
Q
E
Site 133
S776
C
T
S
S
T
I
P
S
S
S
Q
E
K
D
P
Site 134
S777
T
S
S
T
I
P
S
S
S
Q
E
K
D
P
K
Site 135
S778
S
S
T
I
P
S
S
S
Q
E
K
D
P
K
I
Site 136
T787
E
K
D
P
K
I
K
T
E
T
S
E
E
G
S
Site 137
S790
P
K
I
K
T
E
T
S
E
E
G
S
G
D
L
Site 138
S794
T
E
T
S
E
E
G
S
G
D
L
D
N
L
D
Site 139
T808
D
A
I
L
G
D
L
T
S
S
D
F
Y
N
N
Site 140
S809
A
I
L
G
D
L
T
S
S
D
F
Y
N
N
S
Site 141
S810
I
L
G
D
L
T
S
S
D
F
Y
N
N
S
I
Site 142
Y813
D
L
T
S
S
D
F
Y
N
N
S
I
S
S
N
Site 143
S816
S
S
D
F
Y
N
N
S
I
S
S
N
G
S
H
Site 144
S818
D
F
Y
N
N
S
I
S
S
N
G
S
H
L
G
Site 145
S819
F
Y
N
N
S
I
S
S
N
G
S
H
L
G
T
Site 146
S822
N
S
I
S
S
N
G
S
H
L
G
T
K
Q
Q
Site 147
T826
S
N
G
S
H
L
G
T
K
Q
Q
V
F
Q
G
Site 148
S836
Q
V
F
Q
G
T
N
S
L
G
L
K
S
S
Q
Site 149
S841
T
N
S
L
G
L
K
S
S
Q
S
V
Q
S
I
Site 150
S842
N
S
L
G
L
K
S
S
Q
S
V
Q
S
I
R
Site 151
S844
L
G
L
K
S
S
Q
S
V
Q
S
I
R
P
P
Site 152
S847
K
S
S
Q
S
V
Q
S
I
R
P
P
Y
N
R
Site 153
Y852
V
Q
S
I
R
P
P
Y
N
R
A
V
S
L
D
Site 154
S857
P
P
Y
N
R
A
V
S
L
D
S
P
V
S
V
Site 155
S860
N
R
A
V
S
L
D
S
P
V
S
V
G
S
S
Site 156
S863
V
S
L
D
S
P
V
S
V
G
S
S
P
P
V
Site 157
S866
D
S
P
V
S
V
G
S
S
P
P
V
K
N
I
Site 158
S867
S
P
V
S
V
G
S
S
P
P
V
K
N
I
S
Site 159
S874
S
P
P
V
K
N
I
S
A
F
P
M
L
P
K
Site 160
S894
G
N
P
R
M
M
D
S
Q
E
N
Y
G
S
S
Site 161
Y898
M
M
D
S
Q
E
N
Y
G
S
S
M
G
G
P
Site 162
S900
D
S
Q
E
N
Y
G
S
S
M
G
G
P
N
R
Site 163
T910
G
G
P
N
R
N
V
T
V
T
Q
T
P
S
S
Site 164
T912
P
N
R
N
V
T
V
T
Q
T
P
S
S
G
D
Site 165
T914
R
N
V
T
V
T
Q
T
P
S
S
G
D
W
G
Site 166
S917
T
V
T
Q
T
P
S
S
G
D
W
G
L
P
N
Site 167
S925
G
D
W
G
L
P
N
S
K
A
G
R
M
E
P
Site 168
S935
G
R
M
E
P
M
N
S
N
S
M
G
R
P
G
Site 169
S937
M
E
P
M
N
S
N
S
M
G
R
P
G
G
D
Site 170
Y945
M
G
R
P
G
G
D
Y
N
T
S
L
P
R
P
Site 171
T947
R
P
G
G
D
Y
N
T
S
L
P
R
P
A
L
Site 172
S948
P
G
G
D
Y
N
T
S
L
P
R
P
A
L
G
Site 173
S957
P
R
P
A
L
G
G
S
I
P
T
L
P
L
R
Site 174
S965
I
P
T
L
P
L
R
S
N
S
I
P
G
A
R
Site 175
S967
T
L
P
L
R
S
N
S
I
P
G
A
R
P
V
Site 176
Y998
M
G
M
G
A
N
P
Y
G
Q
A
A
A
S
N
Site 177
S1009
A
A
S
N
Q
L
G
S
W
P
D
G
M
L
S
Site 178
S1016
S
W
P
D
G
M
L
S
M
E
Q
V
S
H
G
Site 179
S1033
N
R
P
L
L
R
N
S
L
D
D
L
V
G
P
Site 180
S1042
D
D
L
V
G
P
P
S
N
L
E
G
Q
S
D
Site 181
S1048
P
S
N
L
E
G
Q
S
D
E
R
A
L
L
D
Site 182
T1059
A
L
L
D
Q
L
H
T
L
L
S
N
T
D
A
Site 183
S1062
D
Q
L
H
T
L
L
S
N
T
D
A
T
G
L
Site 184
T1064
L
H
T
L
L
S
N
T
D
A
T
G
L
E
E
Site 185
T1067
L
L
S
N
T
D
A
T
G
L
E
E
I
D
R
Site 186
T1114
K
A
G
L
Y
G
Q
T
Y
P
A
Q
G
P
P
Site 187
Y1115
A
G
L
Y
G
Q
T
Y
P
A
Q
G
P
P
M
Site 188
S1132
G
F
H
L
Q
G
Q
S
P
S
F
N
S
M
M
Site 189
S1134
H
L
Q
G
Q
S
P
S
F
N
S
M
M
N
Q
Site 190
T1164
A
N
I
M
R
P
R
T
N
T
P
K
Q
L
R
Site 191
T1166
I
M
R
P
R
T
N
T
P
K
Q
L
R
M
Q
Site 192
S1216
M
M
Q
P
Q
V
S
S
Q
Q
G
F
L
N
A
Site 193
S1230
A
Q
M
V
A
Q
R
S
R
E
L
L
S
H
H
Site 194
S1235
Q
R
S
R
E
L
L
S
H
H
F
R
Q
Q
R
Site 195
T1277
Q
Q
Q
Q
Q
Q
Q
T
Q
A
F
S
P
P
P
Site 196
S1281
Q
Q
Q
T
Q
A
F
S
P
P
P
N
V
T
A
Site 197
T1287
F
S
P
P
P
N
V
T
A
S
P
S
M
D
G
Site 198
S1289
P
P
P
N
V
T
A
S
P
S
M
D
G
L
L
Site 199
T1300
D
G
L
L
A
G
P
T
M
P
Q
A
P
P
Q
Site 200
Y1311
A
P
P
Q
Q
F
P
Y
Q
P
N
Y
G
M
G
Site 201
Y1315
Q
F
P
Y
Q
P
N
Y
G
M
G
Q
Q
P
D
Site 202
S1329
D
P
A
F
G
R
V
S
S
P
P
N
A
M
M
Site 203
S1330
P
A
F
G
R
V
S
S
P
P
N
A
M
M
S
Site 204
S1337
S
P
P
N
A
M
M
S
S
R
M
G
P
S
Q
Site 205
S1355
M
Q
H
P
Q
A
A
S
I
Y
Q
S
S
E
M
Site 206
Y1357
H
P
Q
A
A
S
I
Y
Q
S
S
E
M
K
G
Site 207
S1359
Q
A
A
S
I
Y
Q
S
S
E
M
K
G
W
P
Site 208
S1360
A
A
S
I
Y
Q
S
S
E
M
K
G
W
P
S
Site 209
S1374
S
G
N
L
A
R
N
S
S
F
S
Q
Q
Q
F
Site 210
S1375
G
N
L
A
R
N
S
S
F
S
Q
Q
Q
F
A
Site 211
S1377
L
A
R
N
S
S
F
S
Q
Q
Q
F
A
H
Q
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation