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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
NUMBL
Full Name:
Numb-like protein
Alias:
CAG3A; CTG3a; NUMBLIKE; Numb-like; NUMBR; Numb-R; TNRC23
Type:
Cell development/differentiation
Mass (Da):
64891
Number AA:
609
UniProt ID:
Q9Y6R0
International Prot ID:
IPI00002560
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0044424
GO:0044464
Uniprot
OncoNet
Molecular Function:
GO:0005515
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0007399
GO:0007405
GO:0007409
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S8
M
S
R
S
A
A
A
S
G
G
P
R
R
P
E
Site 2
T31
G
A
P
G
P
P
E
T
C
R
T
E
P
D
G
Site 3
T34
G
P
P
E
T
C
R
T
E
P
D
G
A
G
T
Site 4
S48
T
M
N
K
L
R
Q
S
L
R
R
R
K
P
A
Site 5
Y56
L
R
R
R
K
P
A
Y
V
P
E
A
S
R
P
Site 6
T77
E
D
A
V
R
K
G
T
C
S
F
P
V
R
Y
Site 7
S79
A
V
R
K
G
T
C
S
F
P
V
R
Y
L
G
Site 8
S116
M
G
R
K
S
V
K
S
V
L
W
V
S
A
D
Site 9
T132
L
R
V
V
D
D
K
T
K
D
L
L
V
D
Q
Site 10
S145
D
Q
T
I
E
K
V
S
F
C
A
P
D
R
N
Site 11
S158
R
N
L
D
K
A
F
S
Y
I
C
R
D
G
T
Site 12
Y159
N
L
D
K
A
F
S
Y
I
C
R
D
G
T
T
Site 13
S180
C
F
L
A
L
K
D
S
G
E
R
L
S
H
A
Site 14
S185
K
D
S
G
E
R
L
S
H
A
V
G
C
A
F
Site 15
T209
R
E
K
E
C
G
V
T
A
A
F
D
A
S
R
Site 16
S218
A
F
D
A
S
R
T
S
F
A
R
E
G
S
F
Site 17
S224
T
S
F
A
R
E
G
S
F
R
L
S
G
G
G
Site 18
S228
R
E
G
S
F
R
L
S
G
G
G
R
P
A
E
Site 19
T251
A
E
A
A
A
A
P
T
V
A
P
G
P
A
Q
Site 20
S263
P
A
Q
P
G
H
V
S
P
T
P
A
T
T
S
Site 21
T265
Q
P
G
H
V
S
P
T
P
A
T
T
S
P
G
Site 22
T268
H
V
S
P
T
P
A
T
T
S
P
G
E
K
G
Site 23
S270
S
P
T
P
A
T
T
S
P
G
E
K
G
E
A
Site 24
T279
G
E
K
G
E
A
G
T
P
V
A
A
G
T
T
Site 25
S305
E
Q
L
V
R
Q
G
S
F
R
G
F
P
A
L
Site 26
S313
F
R
G
F
P
A
L
S
Q
K
N
S
P
F
K
Site 27
S317
P
A
L
S
Q
K
N
S
P
F
K
R
Q
L
S
Site 28
S324
S
P
F
K
R
Q
L
S
L
R
L
N
E
L
P
Site 29
S332
L
R
L
N
E
L
P
S
T
L
Q
R
R
T
D
Site 30
T333
R
L
N
E
L
P
S
T
L
Q
R
R
T
D
F
Site 31
T338
P
S
T
L
Q
R
R
T
D
F
Q
V
K
G
T
Site 32
S357
E
P
P
G
A
G
D
S
D
S
I
N
A
L
C
Site 33
S359
P
G
A
G
D
S
D
S
I
N
A
L
C
T
Q
Site 34
T385
A
P
G
P
P
P
A
T
T
G
T
S
A
W
G
Site 35
T409
F
Q
P
G
H
K
R
T
P
S
E
A
E
R
W
Site 36
S411
P
G
H
K
R
T
P
S
E
A
E
R
W
L
E
Site 37
S421
E
R
W
L
E
E
V
S
Q
V
A
K
A
Q
Q
Site 38
S449
Q
Q
Q
Q
Q
A
A
S
V
A
P
V
P
T
M
Site 39
Y494
Q
P
P
F
V
P
A
Y
P
G
L
G
Y
P
P
Site 40
Y499
P
A
Y
P
G
L
G
Y
P
P
M
P
R
V
P
Site 41
S547
F
P
P
P
A
I
P
S
A
P
G
S
Q
A
R
Site 42
S551
A
I
P
S
A
P
G
S
Q
A
R
P
R
P
N
Site 43
T589
A
A
L
E
G
K
A
T
V
E
K
P
S
N
P
Site 44
S594
K
A
T
V
E
K
P
S
N
P
F
S
G
D
L
Site 45
S598
E
K
P
S
N
P
F
S
G
D
L
Q
K
T
F
Site 46
T604
F
S
G
D
L
Q
K
T
F
E
I
E
L
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation