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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
DGK-B
Full Name:
Diacylglycerol kinase beta
Alias:
90 kDa diacylglycerol kinase; DAG kinase beta; DAGK2; DGK; DGKB; DGK-beta; Diacylglycerol kinase, beta; Diacylglycerol kinase, beta 90kDa; Diglyceride kinase; Diglyceride kinase beta; KDGB; KIAA0718
Type:
EC 2.7.1.107; Lipid Metabolism - glycerophospholipid; Lipid Metabolism - glycerolipid; Kinase, lipid
Mass (Da):
90595
Number AA:
804
UniProt ID:
Q9Y6T7
International Prot ID:
IPI00002590
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0005509
GO:0004143
PhosphoSite+
KinaseNET
Biological Process:
GO:0007205
GO:0007242
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S11
Q
E
K
W
A
H
L
S
P
S
E
F
S
Q
L
Site 2
S13
K
W
A
H
L
S
P
S
E
F
S
Q
L
Q
K
Site 3
Y21
E
F
S
Q
L
Q
K
Y
A
E
Y
S
T
K
K
Site 4
Y45
G
N
G
V
L
A
K
Y
N
P
E
G
K
Q
D
Site 5
S88
A
H
L
F
M
S
F
S
N
K
F
P
H
S
S
Site 6
S94
F
S
N
K
F
P
H
S
S
P
M
V
K
S
K
Site 7
S95
S
N
K
F
P
H
S
S
P
M
V
K
S
K
P
Site 8
S100
H
S
S
P
M
V
K
S
K
P
A
L
L
S
G
Site 9
S106
K
S
K
P
A
L
L
S
G
G
L
R
M
N
K
Site 10
T117
R
M
N
K
G
A
I
T
P
P
R
T
T
S
P
Site 11
T121
G
A
I
T
P
P
R
T
T
S
P
A
N
T
C
Site 12
T122
A
I
T
P
P
R
T
T
S
P
A
N
T
C
S
Site 13
S123
I
T
P
P
R
T
T
S
P
A
N
T
C
S
P
Site 14
T127
R
T
T
S
P
A
N
T
C
S
P
E
V
I
H
Site 15
S129
T
S
P
A
N
T
C
S
P
E
V
I
H
L
K
Site 16
S143
K
D
I
V
C
Y
L
S
L
L
E
R
G
R
P
Site 17
Y161
L
E
F
M
F
R
L
Y
D
T
D
G
N
G
F
Site 18
S171
D
G
N
G
F
L
D
S
S
E
L
E
N
I
I
Site 19
S172
G
N
G
F
L
D
S
S
E
L
E
N
I
I
S
Site 20
S179
S
E
L
E
N
I
I
S
Q
M
M
H
V
A
E
Site 21
T193
E
Y
L
E
W
D
V
T
E
L
N
P
I
L
H
Site 22
Y208
E
M
M
E
E
I
D
Y
D
H
D
G
T
V
S
Site 23
T213
I
D
Y
D
H
D
G
T
V
S
L
E
E
W
I
Site 24
S215
Y
D
H
D
G
T
V
S
L
E
E
W
I
Q
G
Site 25
Y257
K
H
F
N
K
P
A
Y
C
N
L
C
L
N
M
Site 26
T297
A
P
P
S
C
I
K
T
Y
V
K
S
K
R
N
Site 27
Y298
P
P
S
C
I
K
T
Y
V
K
S
K
R
N
T
Site 28
Y311
N
T
D
V
M
H
H
Y
W
V
E
G
N
C
P
Site 29
S387
T
L
P
T
S
G
V
S
V
P
E
E
R
Q
S
Site 30
S394
S
V
P
E
E
R
Q
S
T
V
K
K
E
K
S
Site 31
T395
V
P
E
E
R
Q
S
T
V
K
K
E
K
S
G
Site 32
S401
S
T
V
K
K
E
K
S
G
S
Q
Q
P
N
K
Site 33
S403
V
K
K
E
K
S
G
S
Q
Q
P
N
K
V
I
Site 34
S420
N
K
M
Q
R
A
N
S
V
T
V
D
G
Q
G
Site 35
T422
M
Q
R
A
N
S
V
T
V
D
G
Q
G
L
Q
Site 36
T431
D
G
Q
G
L
Q
V
T
P
V
P
G
T
H
P
Site 37
S447
L
V
F
V
N
P
K
S
G
G
K
Q
G
E
R
Site 38
Y456
G
K
Q
G
E
R
I
Y
R
K
F
Q
Y
L
L
Site 39
Y461
R
I
Y
R
K
F
Q
Y
L
L
N
P
R
Q
V
Site 40
Y469
L
L
N
P
R
Q
V
Y
S
L
S
G
N
G
P
Site 41
S470
L
N
P
R
Q
V
Y
S
L
S
G
N
G
P
M
Site 42
S472
P
R
Q
V
Y
S
L
S
G
N
G
P
M
P
G
Site 43
Y539
C
L
R
W
G
G
G
Y
E
G
E
N
L
M
K
Site 44
S581
K
G
D
P
V
P
Y
S
I
I
N
N
Y
F
S
Site 45
Y586
P
Y
S
I
I
N
N
Y
F
S
I
G
V
D
A
Site 46
S594
F
S
I
G
V
D
A
S
I
A
H
R
F
H
I
Site 47
Y620
R
M
K
N
K
F
W
Y
F
E
F
G
T
S
E
Site 48
T628
F
E
F
G
T
S
E
T
F
S
A
T
C
K
K
Site 49
S630
F
G
T
S
E
T
F
S
A
T
C
K
K
L
H
Site 50
S639
T
C
K
K
L
H
E
S
V
E
I
E
C
D
G
Site 51
S677
G
S
N
L
W
G
E
S
K
K
R
R
S
H
R
Site 52
S682
G
E
S
K
K
R
R
S
H
R
R
I
E
K
K
Site 53
S691
R
R
I
E
K
K
G
S
D
K
R
T
T
V
T
Site 54
T695
K
K
G
S
D
K
R
T
T
V
T
D
A
K
E
Site 55
T696
K
G
S
D
K
R
T
T
V
T
D
A
K
E
L
Site 56
T698
S
D
K
R
T
T
V
T
D
A
K
E
L
K
F
Site 57
S707
A
K
E
L
K
F
A
S
Q
D
L
S
D
Q
L
Site 58
S711
K
F
A
S
Q
D
L
S
D
Q
L
L
E
V
V
Site 59
Y730
A
M
E
M
G
Q
I
Y
T
G
L
K
S
A
G
Site 60
S735
Q
I
Y
T
G
L
K
S
A
G
R
R
L
A
Q
Site 61
S793
P
K
T
G
L
F
C
S
L
V
K
R
T
R
N
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation