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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
CAPN7
Full Name:
Calpain-7
Alias:
Calpain 7; Calpain like protease; CALPAIN7; CAN7; Of Aspergillus Nidulans PALB; PalB; PALBH
Type:
EC 3.4.22.-; Protease
Mass (Da):
92650
Number AA:
UniProt ID:
Q9Y6W3
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0004198
PhosphoSite+
KinaseNET
Biological Process:
GO:0006508
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S27
R
D
H
E
G
R
Y
S
E
A
V
F
Y
Y
K
Site 2
Y32
R
Y
S
E
A
V
F
Y
Y
K
E
A
A
Q
A
Site 3
Y60
I
Q
E
K
I
T
E
Y
L
E
R
V
Q
A
L
Site 4
S69
E
R
V
Q
A
L
H
S
A
V
Q
S
K
S
A
Site 5
S73
A
L
H
S
A
V
Q
S
K
S
A
D
P
L
K
Site 6
S75
H
S
A
V
Q
S
K
S
A
D
P
L
K
S
K
Site 7
T95
E
R
A
H
F
L
V
T
Q
A
F
D
E
D
E
Site 8
S124
V
D
L
C
L
K
T
S
Y
E
T
A
D
K
V
Site 9
S151
L
D
R
A
E
A
L
S
E
P
L
T
K
P
V
Site 10
T155
E
A
L
S
E
P
L
T
K
P
V
G
K
I
S
Site 11
S163
K
P
V
G
K
I
S
S
T
S
V
K
P
K
P
Site 12
S165
V
G
K
I
S
S
T
S
V
K
P
K
P
P
P
Site 13
S190
P
F
L
E
R
P
Q
S
F
I
S
P
Q
S
C
Site 14
S193
E
R
P
Q
S
F
I
S
P
Q
S
C
D
A
Q
Site 15
S196
Q
S
F
I
S
P
Q
S
C
D
A
Q
G
Q
R
Site 16
T205
D
A
Q
G
Q
R
Y
T
A
E
E
I
E
V
L
Site 17
T214
E
E
I
E
V
L
R
T
T
S
K
I
N
G
I
Site 18
T215
E
I
E
V
L
R
T
T
S
K
I
N
G
I
E
Site 19
S216
I
E
V
L
R
T
T
S
K
I
N
G
I
E
Y
Site 20
Y223
S
K
I
N
G
I
E
Y
V
P
F
M
N
V
D
Site 21
Y237
D
L
R
E
R
F
A
Y
P
M
P
F
C
D
R
Site 22
S251
R
W
G
K
L
P
L
S
P
K
Q
K
T
T
F
Site 23
T257
L
S
P
K
Q
K
T
T
F
S
K
W
V
R
P
Site 24
S259
P
K
Q
K
T
T
F
S
K
W
V
R
P
E
D
Site 25
T276
N
N
P
T
M
I
Y
T
V
S
S
F
S
I
K
Site 26
Y302
S
L
A
I
S
A
A
Y
E
R
R
F
N
K
K
Site 27
Y316
K
L
I
T
G
I
I
Y
P
Q
N
K
D
G
E
Site 28
Y326
N
K
D
G
E
P
E
Y
N
P
C
G
K
Y
M
Site 29
Y332
E
Y
N
P
C
G
K
Y
M
V
K
L
H
L
N
Site 30
S362
H
K
G
E
L
L
C
S
Y
S
N
N
K
S
E
Site 31
Y363
K
G
E
L
L
C
S
Y
S
N
N
K
S
E
L
Site 32
S364
G
E
L
L
C
S
Y
S
N
N
K
S
E
L
W
Site 33
S368
C
S
Y
S
N
N
K
S
E
L
W
V
S
L
I
Site 34
S373
N
K
S
E
L
W
V
S
L
I
E
K
A
Y
M
Site 35
Y386
Y
M
K
V
M
G
G
Y
D
F
P
G
S
N
S
Site 36
S391
G
G
Y
D
F
P
G
S
N
S
N
I
D
L
H
Site 37
S393
Y
D
F
P
G
S
N
S
N
I
D
L
H
A
L
Site 38
S412
P
E
R
I
A
M
H
S
D
S
Q
T
F
S
K
Site 39
S414
R
I
A
M
H
S
D
S
Q
T
F
S
K
D
N
Site 40
T416
A
M
H
S
D
S
Q
T
F
S
K
D
N
S
F
Site 41
S418
H
S
D
S
Q
T
F
S
K
D
N
S
F
R
M
Site 42
S422
Q
T
F
S
K
D
N
S
F
R
M
L
Y
Q
R
Site 43
Y427
D
N
S
F
R
M
L
Y
Q
R
F
H
K
G
D
Site 44
Y489
H
L
R
W
K
G
R
Y
S
E
N
D
V
K
N
Site 45
T498
E
N
D
V
K
N
W
T
P
E
L
Q
K
Y
L
Site 46
Y504
W
T
P
E
L
Q
K
Y
L
N
F
D
P
R
T
Site 47
T511
Y
L
N
F
D
P
R
T
A
Q
K
I
D
N
G
Site 48
Y530
S
W
D
D
L
C
Q
Y
Y
D
V
I
Y
L
S
Site 49
Y535
C
Q
Y
Y
D
V
I
Y
L
S
W
N
P
G
L
Site 50
Y564
Q
G
P
V
K
D
A
Y
S
L
A
N
N
P
Q
Site 51
S565
G
P
V
K
D
A
Y
S
L
A
N
N
P
Q
Y
Site 52
Y572
S
L
A
N
N
P
Q
Y
K
L
E
V
Q
C
P
Site 53
T594
V
L
L
S
R
H
I
T
D
K
D
D
F
A
N
Site 54
Y611
E
F
I
T
M
V
V
Y
K
T
D
G
K
K
V
Site 55
T613
I
T
M
V
V
Y
K
T
D
G
K
K
V
Y
Y
Site 56
Y619
K
T
D
G
K
K
V
Y
Y
P
A
D
P
P
P
Site 57
Y620
T
D
G
K
K
V
Y
Y
P
A
D
P
P
P
Y
Site 58
Y627
Y
P
A
D
P
P
P
Y
I
D
G
I
R
I
N
Site 59
S635
I
D
G
I
R
I
N
S
P
H
Y
L
T
K
I
Site 60
Y638
I
R
I
N
S
P
H
Y
L
T
K
I
K
L
T
Site 61
T646
L
T
K
I
K
L
T
T
P
G
T
H
T
F
T
Site 62
T653
T
P
G
T
H
T
F
T
L
V
V
S
Q
Y
E
Site 63
S657
H
T
F
T
L
V
V
S
Q
Y
E
K
Q
N
T
Site 64
Y659
F
T
L
V
V
S
Q
Y
E
K
Q
N
T
I
H
Site 65
T664
S
Q
Y
E
K
Q
N
T
I
H
Y
T
V
R
V
Site 66
Y667
E
K
Q
N
T
I
H
Y
T
V
R
V
Y
S
A
Site 67
T668
K
Q
N
T
I
H
Y
T
V
R
V
Y
S
A
C
Site 68
S673
H
Y
T
V
R
V
Y
S
A
C
S
F
T
F
S
Site 69
S680
S
A
C
S
F
T
F
S
K
I
P
S
P
Y
T
Site 70
S684
F
T
F
S
K
I
P
S
P
Y
T
L
S
K
R
Site 71
T687
S
K
I
P
S
P
Y
T
L
S
K
R
I
N
G
Site 72
S689
I
P
S
P
Y
T
L
S
K
R
I
N
G
K
W
Site 73
S697
K
R
I
N
G
K
W
S
G
Q
S
A
G
G
C
Site 74
Y717
T
H
K
N
N
P
I
Y
Q
F
H
I
E
K
T
Site 75
Y737
E
L
R
G
P
R
Q
Y
S
V
G
F
E
V
V
Site 76
S738
L
R
G
P
R
Q
Y
S
V
G
F
E
V
V
T
Site 77
S761
P
H
G
F
L
R
K
S
S
G
D
Y
R
C
G
Site 78
S762
H
G
F
L
R
K
S
S
G
D
Y
R
C
G
F
Site 79
Y765
L
R
K
S
S
G
D
Y
R
C
G
F
C
Y
L
Site 80
Y771
D
Y
R
C
G
F
C
Y
L
E
L
E
N
I
P
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation