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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
PIAS3
Full Name:
E3 SUMO-protein ligase PIAS3
Alias:
Protein inhibitor of activated STAT 3
Type:
Nuclear speck, Nucleus protein
Mass (Da):
68017
Number AA:
628
UniProt ID:
Q9Y6X2
International Prot ID:
IPI00005789
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0016607
Uniprot
OncoNet
Molecular Function:
GO:0019899
GO:0003676
GO:0008022
PhosphoSite+
KinaseNET
Biological Process:
GO:0019941
GO:0033235
GO:0045449
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S13
E
L
K
H
M
V
M
S
F
R
V
S
E
L
Q
Site 2
S31
G
F
A
G
R
N
K
S
G
R
K
H
E
L
L
Site 3
S52
L
K
S
S
C
A
P
S
V
Q
M
K
I
K
E
Site 4
Y61
Q
M
K
I
K
E
L
Y
R
R
R
F
P
R
K
Site 5
T69
R
R
R
F
P
R
K
T
L
G
P
S
D
L
S
Site 6
S73
P
R
K
T
L
G
P
S
D
L
S
L
L
S
L
Site 7
S79
P
S
D
L
S
L
L
S
L
P
P
G
T
S
P
Site 8
S85
L
S
L
P
P
G
T
S
P
V
G
S
P
G
P
Site 9
T105
P
T
L
L
A
P
G
T
L
L
G
P
K
R
E
Site 10
T128
Q
P
V
H
P
D
V
T
M
K
P
L
P
F
Y
Site 11
Y135
T
M
K
P
L
P
F
Y
E
V
Y
G
E
L
I
Site 12
T145
Y
G
E
L
I
R
P
T
T
L
A
S
T
S
S
Site 13
T146
G
E
L
I
R
P
T
T
L
A
S
T
S
S
Q
Site 14
S149
I
R
P
T
T
L
A
S
T
S
S
Q
R
F
E
Site 15
S151
P
T
T
L
A
S
T
S
S
Q
R
F
E
E
A
Site 16
S152
T
T
L
A
S
T
S
S
Q
R
F
E
E
A
H
Site 17
T161
R
F
E
E
A
H
F
T
F
A
L
T
P
Q
Q
Site 18
Y186
L
P
G
A
K
C
D
Y
T
I
Q
V
Q
L
R
Site 19
T187
P
G
A
K
C
D
Y
T
I
Q
V
Q
L
R
F
Site 20
Y206
T
S
C
P
Q
E
D
Y
F
P
P
N
L
F
V
Site 21
Y225
K
L
C
P
L
P
G
Y
L
P
P
T
K
N
G
Site 22
T229
L
P
G
Y
L
P
P
T
K
N
G
A
E
P
K
Site 23
S239
G
A
E
P
K
R
P
S
R
P
I
N
I
T
P
Site 24
T245
P
S
R
P
I
N
I
T
P
L
A
R
L
S
A
Site 25
Y270
S
S
E
F
G
R
N
Y
S
L
S
V
Y
L
V
Site 26
S271
S
E
F
G
R
N
Y
S
L
S
V
Y
L
V
R
Site 27
S273
F
G
R
N
Y
S
L
S
V
Y
L
V
R
Q
L
Site 28
Y275
R
N
Y
S
L
S
V
Y
L
V
R
Q
L
T
A
Site 29
S300
G
I
R
N
P
D
H
S
R
A
L
I
K
E
K
Site 30
S314
K
L
T
A
D
P
D
S
E
V
A
T
T
S
L
Site 31
T318
D
P
D
S
E
V
A
T
T
S
L
R
V
S
L
Site 32
T319
P
D
S
E
V
A
T
T
S
L
R
V
S
L
M
Site 33
Y354
Q
S
F
D
A
A
L
Y
L
Q
M
N
E
K
K
Site 34
Y375
V
C
D
K
K
A
P
Y
E
S
L
I
I
D
G
Site 35
S392
M
E
I
L
S
S
C
S
D
C
D
E
I
Q
F
Site 36
S415
M
K
P
K
K
E
A
S
E
V
C
P
P
P
G
Site 37
Y423
E
V
C
P
P
P
G
Y
G
L
D
G
L
Q
Y
Site 38
Y430
Y
G
L
D
G
L
Q
Y
S
P
V
Q
G
G
D
Site 39
S431
G
L
D
G
L
Q
Y
S
P
V
Q
G
G
D
P
Site 40
S439
P
V
Q
G
G
D
P
S
E
N
K
K
K
V
E
Site 41
T451
K
V
E
V
I
D
L
T
I
E
S
S
S
D
E
Site 42
S454
V
I
D
L
T
I
E
S
S
S
D
E
E
D
L
Site 43
S455
I
D
L
T
I
E
S
S
S
D
E
E
D
L
P
Site 44
S456
D
L
T
I
E
S
S
S
D
E
E
D
L
P
P
Site 45
S469
P
P
T
K
K
H
C
S
V
T
S
A
A
I
P
Site 46
T486
P
G
S
K
G
V
L
T
S
G
H
Q
P
S
S
Site 47
S487
G
S
K
G
V
L
T
S
G
H
Q
P
S
S
V
Site 48
S492
L
T
S
G
H
Q
P
S
S
V
L
R
S
P
A
Site 49
S493
T
S
G
H
Q
P
S
S
V
L
R
S
P
A
M
Site 50
S497
Q
P
S
S
V
L
R
S
P
A
M
G
T
L
G
Site 51
S509
T
L
G
G
D
F
L
S
S
L
P
L
H
E
Y
Site 52
S510
L
G
G
D
F
L
S
S
L
P
L
H
E
Y
P
Site 53
Y516
S
S
L
P
L
H
E
Y
P
P
A
F
P
L
G
Site 54
S533
I
Q
G
L
D
L
F
S
F
L
Q
T
E
S
Q
Site 55
T537
D
L
F
S
F
L
Q
T
E
S
Q
H
Y
G
P
Site 56
S539
F
S
F
L
Q
T
E
S
Q
H
Y
G
P
S
V
Site 57
Y542
L
Q
T
E
S
Q
H
Y
G
P
S
V
I
T
S
Site 58
S545
E
S
Q
H
Y
G
P
S
V
I
T
S
L
D
E
Site 59
S549
Y
G
P
S
V
I
T
S
L
D
E
Q
D
A
L
Site 60
Y562
A
L
G
H
F
F
Q
Y
R
G
T
P
S
H
F
Site 61
T565
H
F
F
Q
Y
R
G
T
P
S
H
F
L
G
P
Site 62
S579
P
L
A
P
T
L
G
S
S
H
C
S
A
T
P
Site 63
S583
T
L
G
S
S
H
C
S
A
T
P
A
P
P
P
Site 64
T585
G
S
S
H
C
S
A
T
P
A
P
P
P
G
R
Site 65
S613
G
H
G
G
P
L
P
S
G
P
S
L
T
G
C
Site 66
S616
G
P
L
P
S
G
P
S
L
T
G
C
R
S
D
Site 67
S622
P
S
L
T
G
C
R
S
D
I
I
S
L
D
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation