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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
MYO16
Full Name:
Myosin-XVI
Alias:
KIAA0865; Myo16b; Myosin heavy chain Myr 8; Myosin XVI; MYR8; RP11-54H7.1; Unconventional myosin-16
Type:
Contractile protein; Actin binding protein; Cell cycle regulation
Mass (Da):
206110
Number AA:
1858
UniProt ID:
Q9Y6X6
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0016459
GO:0005654
GO:0048471
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0051015
GO:0003774
PhosphoSite+
KinaseNET
Biological Process:
GO:0021549
GO:0045749
GO:0008285
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y31
R
C
E
Q
I
K
A
Y
Y
E
R
E
K
A
F
Site 2
Y32
C
E
Q
I
K
A
Y
Y
E
R
E
K
A
F
Q
Site 3
T88
K
E
G
A
D
P
H
T
L
V
S
S
G
G
S
Site 4
S91
A
D
P
H
T
L
V
S
S
G
G
S
L
L
H
Site 5
Y165
N
G
N
I
P
L
D
Y
A
V
E
G
T
E
S
Site 6
T178
E
S
S
S
I
L
L
T
Y
L
D
E
N
G
V
Site 7
Y179
S
S
S
I
L
L
T
Y
L
D
E
N
G
V
D
Site 8
T188
D
E
N
G
V
D
L
T
S
L
R
Q
M
K
L
Site 9
S189
E
N
G
V
D
L
T
S
L
R
Q
M
K
L
Q
Site 10
S200
M
K
L
Q
R
P
M
S
M
L
T
D
V
K
H
Site 11
T203
Q
R
P
M
S
M
L
T
D
V
K
H
F
L
S
Site 12
Y255
L
N
I
V
D
D
Q
Y
W
T
P
L
H
L
A
Site 13
T257
I
V
D
D
Q
Y
W
T
P
L
H
L
A
A
K
Site 14
Y265
P
L
H
L
A
A
K
Y
G
Q
T
N
L
V
K
Site 15
S292
N
C
N
E
E
K
A
S
D
I
A
A
S
E
F
Site 16
S320
E
K
M
K
E
P
L
S
A
S
T
L
A
Q
E
Site 17
S356
L
P
I
A
K
Q
D
S
L
L
E
K
D
I
M
Site 18
S376
K
G
L
C
K
Q
Q
S
Q
D
S
I
P
E
N
Site 19
S379
C
K
Q
Q
S
Q
D
S
I
P
E
N
P
M
M
Site 20
S387
I
P
E
N
P
M
M
S
G
S
T
K
P
E
Q
Site 21
S389
E
N
P
M
M
S
G
S
T
K
P
E
Q
V
K
Site 22
T408
A
P
N
D
D
L
A
T
L
S
E
L
N
D
G
Site 23
S410
N
D
D
L
A
T
L
S
E
L
N
D
G
S
L
Site 24
S416
L
S
E
L
N
D
G
S
L
L
Y
E
I
Q
K
Site 25
Y419
L
N
D
G
S
L
L
Y
E
I
Q
K
R
F
G
Site 26
Y450
P
Y
K
E
L
P
I
Y
S
S
M
V
S
Q
L
Site 27
S451
Y
K
E
L
P
I
Y
S
S
M
V
S
Q
L
Y
Site 28
S455
P
I
Y
S
S
M
V
S
Q
L
Y
F
S
S
S
Site 29
Y458
S
S
M
V
S
Q
L
Y
F
S
S
S
G
K
L
Site 30
S461
V
S
Q
L
Y
F
S
S
S
G
K
L
C
S
S
Site 31
S462
S
Q
L
Y
F
S
S
S
G
K
L
C
S
S
L
Site 32
S467
S
S
S
G
K
L
C
S
S
L
P
P
H
L
F
Site 33
S468
S
S
G
K
L
C
S
S
L
P
P
H
L
F
S
Site 34
S496
R
P
Q
C
F
I
L
S
G
E
R
G
S
G
K
Site 35
S501
I
L
S
G
E
R
G
S
G
K
S
E
A
S
K
Site 36
S504
G
E
R
G
S
G
K
S
E
A
S
K
Q
I
I
Site 37
S507
G
S
G
K
S
E
A
S
K
Q
I
I
R
H
L
Site 38
T515
K
Q
I
I
R
H
L
T
C
R
A
G
A
S
R
Site 39
T524
R
A
G
A
S
R
A
T
L
D
S
R
F
K
H
Site 40
S527
A
S
R
A
T
L
D
S
R
F
K
H
V
V
C
Site 41
T544
E
A
F
G
H
A
K
T
T
L
N
D
L
S
S
Site 42
T545
A
F
G
H
A
K
T
T
L
N
D
L
S
S
C
Site 43
T569
C
E
R
K
Q
Q
L
T
G
A
R
I
Y
T
Y
Site 44
Y574
Q
L
T
G
A
R
I
Y
T
Y
L
L
E
K
S
Site 45
T575
L
T
G
A
R
I
Y
T
Y
L
L
E
K
S
R
Site 46
Y576
T
G
A
R
I
Y
T
Y
L
L
E
K
S
R
L
Site 47
S581
Y
T
Y
L
L
E
K
S
R
L
V
S
Q
P
L
Site 48
S585
L
E
K
S
R
L
V
S
Q
P
L
G
Q
S
N
Site 49
S604
Y
L
L
M
D
G
L
S
A
E
E
K
Y
G
L
Site 50
Y621
N
N
L
C
A
H
R
Y
L
N
Q
T
I
Q
D
Site 51
T625
A
H
R
Y
L
N
Q
T
I
Q
D
D
A
S
T
Site 52
S631
Q
T
I
Q
D
D
A
S
T
G
E
R
S
L
N
Site 53
T632
T
I
Q
D
D
A
S
T
G
E
R
S
L
N
R
Site 54
S636
D
A
S
T
G
E
R
S
L
N
R
E
K
L
A
Site 55
T678
H
L
G
D
I
R
F
T
A
L
N
E
G
N
S
Site 56
S685
T
A
L
N
E
G
N
S
A
F
V
S
D
L
Q
Site 57
S689
E
G
N
S
A
F
V
S
D
L
Q
L
L
E
Q
Site 58
T714
E
L
A
S
A
L
T
T
D
I
Q
Y
F
K
G
Site 59
S743
F
R
D
L
L
A
K
S
L
Y
S
R
L
F
S
Site 60
S762
T
M
N
S
C
L
H
S
Q
D
E
Q
K
S
M
Site 61
S768
H
S
Q
D
E
Q
K
S
M
Q
T
L
D
I
G
Site 62
Y805
T
N
E
K
M
H
H
Y
I
N
E
V
L
F
L
Site 63
S830
V
T
M
E
T
A
Y
S
P
G
N
Q
N
G
V
Site 64
T850
Q
K
P
S
G
F
L
T
L
L
D
E
E
S
Q
Site 65
S856
L
T
L
L
D
E
E
S
Q
M
I
W
S
V
E
Site 66
S872
N
F
P
K
K
L
Q
S
L
L
E
S
S
N
T
Site 67
S876
K
L
Q
S
L
L
E
S
S
N
T
N
A
V
Y
Site 68
T879
S
L
L
E
S
S
N
T
N
A
V
Y
S
P
M
Site 69
S884
S
N
T
N
A
V
Y
S
P
M
K
D
G
N
G
Site 70
S925
A
I
E
K
N
K
D
S
L
S
Q
N
L
L
F
Site 71
S927
E
K
N
K
D
S
L
S
Q
N
L
L
F
V
M
Site 72
S948
V
I
N
H
L
F
Q
S
K
L
S
Q
T
G
S
Site 73
S951
H
L
F
Q
S
K
L
S
Q
T
G
S
L
V
S
Site 74
S955
S
K
L
S
Q
T
G
S
L
V
S
A
Y
P
S
Site 75
S958
S
Q
T
G
S
L
V
S
A
Y
P
S
F
K
F
Site 76
Y960
T
G
S
L
V
S
A
Y
P
S
F
K
F
R
G
Site 77
S962
S
L
V
S
A
Y
P
S
F
K
F
R
G
H
K
Site 78
S970
F
K
F
R
G
H
K
S
A
L
L
S
K
K
M
Site 79
S974
G
H
K
S
A
L
L
S
K
K
M
T
A
S
S
Site 80
S981
S
K
K
M
T
A
S
S
I
I
G
E
N
K
N
Site 81
Y989
I
I
G
E
N
K
N
Y
L
E
L
S
K
L
L
Site 82
T1003
L
K
K
K
G
T
S
T
F
L
Q
R
L
E
R
Site 83
T1015
L
E
R
G
D
P
V
T
I
A
S
Q
L
R
K
Site 84
S1018
G
D
P
V
T
I
A
S
Q
L
R
K
S
L
M
Site 85
T1052
N
N
S
K
L
P
D
T
F
D
N
F
Y
V
S
Site 86
Y1057
P
D
T
F
D
N
F
Y
V
S
A
Q
L
Q
Y
Site 87
Y1076
E
M
V
K
I
F
R
Y
G
Y
P
V
R
L
S
Site 88
Y1078
V
K
I
F
R
Y
G
Y
P
V
R
L
S
F
S
Site 89
S1083
Y
G
Y
P
V
R
L
S
F
S
D
F
L
S
R
Site 90
S1085
Y
P
V
R
L
S
F
S
D
F
L
S
R
Y
K
Site 91
S1089
L
S
F
S
D
F
L
S
R
Y
K
P
L
A
D
Site 92
Y1091
F
S
D
F
L
S
R
Y
K
P
L
A
D
T
F
Site 93
T1097
R
Y
K
P
L
A
D
T
F
L
R
E
K
K
E
Site 94
Y1134
V
R
K
V
F
L
K
Y
W
H
A
D
Q
L
N
Site 95
S1172
Q
H
L
L
Q
R
I
S
I
R
Q
Q
E
V
T
Site 96
T1179
S
I
R
Q
Q
E
V
T
S
I
N
S
F
L
Q
Site 97
S1180
I
R
Q
Q
E
V
T
S
I
N
S
F
L
Q
N
Site 98
S1183
Q
E
V
T
S
I
N
S
F
L
Q
N
T
E
D
Site 99
Y1196
E
D
M
G
L
K
T
Y
D
A
L
V
I
Q
N
Site 100
S1216
R
E
N
D
R
L
R
S
E
M
N
A
P
Y
H
Site 101
Y1222
R
S
E
M
N
A
P
Y
H
K
E
K
L
E
V
Site 102
S1237
R
N
M
Q
E
E
G
S
K
R
T
D
D
K
S
Site 103
S1244
S
K
R
T
D
D
K
S
G
P
R
H
F
H
P
Site 104
S1252
G
P
R
H
F
H
P
S
S
M
S
V
C
A
A
Site 105
S1253
P
R
H
F
H
P
S
S
M
S
V
C
A
A
V
Site 106
S1279
I
W
S
P
S
L
H
S
V
F
S
M
D
D
S
Site 107
S1282
P
S
L
H
S
V
F
S
M
D
D
S
S
S
L
Site 108
S1286
S
V
F
S
M
D
D
S
S
S
L
P
S
P
R
Site 109
S1287
V
F
S
M
D
D
S
S
S
L
P
S
P
R
K
Site 110
S1288
F
S
M
D
D
S
S
S
L
P
S
P
R
K
Q
Site 111
S1291
D
D
S
S
S
L
P
S
P
R
K
Q
P
P
P
Site 112
T1306
K
P
K
R
D
P
N
T
R
L
S
A
S
Y
E
Site 113
S1309
R
D
P
N
T
R
L
S
A
S
Y
E
A
V
S
Site 114
S1311
P
N
T
R
L
S
A
S
Y
E
A
V
S
A
C
Site 115
S1337
L
A
R
P
R
P
H
S
D
D
Y
S
T
M
K
Site 116
Y1340
P
R
P
H
S
D
D
Y
S
T
M
K
K
I
P
Site 117
S1341
R
P
H
S
D
D
Y
S
T
M
K
K
I
P
P
Site 118
T1342
P
H
S
D
D
Y
S
T
M
K
K
I
P
P
R
Site 119
S1354
P
P
R
K
P
K
R
S
P
N
T
K
L
S
G
Site 120
T1357
K
P
K
R
S
P
N
T
K
L
S
G
S
Y
E
Site 121
S1360
R
S
P
N
T
K
L
S
G
S
Y
E
E
I
S
Site 122
S1362
P
N
T
K
L
S
G
S
Y
E
E
I
S
G
S
Site 123
Y1363
N
T
K
L
S
G
S
Y
E
E
I
S
G
S
R
Site 124
S1367
S
G
S
Y
E
E
I
S
G
S
R
P
G
D
A
Site 125
S1369
S
Y
E
E
I
S
G
S
R
P
G
D
A
R
P
Site 126
S1408
P
P
G
D
E
D
D
S
E
P
V
Y
I
E
M
Site 127
Y1412
E
D
D
S
E
P
V
Y
I
E
M
L
G
H
A
Site 128
S1424
G
H
A
A
R
P
D
S
P
D
P
G
E
S
V
Site 129
S1430
D
S
P
D
P
G
E
S
V
Y
E
E
M
K
C
Site 130
Y1432
P
D
P
G
E
S
V
Y
E
E
M
K
C
C
L
Site 131
S1449
D
G
G
P
G
A
G
S
F
L
L
H
G
A
S
Site 132
T1501
V
F
P
P
T
P
V
T
C
S
P
A
S
D
E
Site 133
S1503
P
P
T
P
V
T
C
S
P
A
S
D
E
S
P
Site 134
S1506
P
V
T
C
S
P
A
S
D
E
S
P
L
T
P
Site 135
S1509
C
S
P
A
S
D
E
S
P
L
T
P
L
E
V
Site 136
T1512
A
S
D
E
S
P
L
T
P
L
E
V
K
K
L
Site 137
Y1528
V
L
E
T
N
L
K
Y
P
V
Q
P
E
G
S
Site 138
S1535
Y
P
V
Q
P
E
G
S
S
P
L
S
P
Q
Y
Site 139
S1536
P
V
Q
P
E
G
S
S
P
L
S
P
Q
Y
S
Site 140
S1539
P
E
G
S
S
P
L
S
P
Q
Y
S
K
S
Q
Site 141
Y1542
S
S
P
L
S
P
Q
Y
S
K
S
Q
K
G
D
Site 142
S1543
S
P
L
S
P
Q
Y
S
K
S
Q
K
G
D
G
Site 143
S1545
L
S
P
Q
Y
S
K
S
Q
K
G
D
G
D
R
Site 144
S1555
G
D
G
D
R
P
A
S
P
G
L
A
L
F
N
Site 145
S1564
G
L
A
L
F
N
G
S
G
R
A
S
P
P
S
Site 146
S1568
F
N
G
S
G
R
A
S
P
P
S
T
P
P
P
Site 147
S1571
S
G
R
A
S
P
P
S
T
P
P
P
P
P
P
Site 148
T1572
G
R
A
S
P
P
S
T
P
P
P
P
P
P
P
Site 149
Y1587
P
G
P
P
P
A
P
Y
R
P
C
A
H
L
A
Site 150
S1622
K
V
H
P
K
P
N
S
A
P
V
A
G
P
C
Site 151
S1631
P
V
A
G
P
C
S
S
F
P
K
I
P
Y
S
Site 152
Y1637
S
S
F
P
K
I
P
Y
S
P
V
K
A
T
R
Site 153
S1638
S
F
P
K
I
P
Y
S
P
V
K
A
T
R
A
Site 154
S1652
A
D
A
R
K
A
G
S
S
A
S
P
P
A
P
Site 155
S1653
D
A
R
K
A
G
S
S
A
S
P
P
A
P
Y
Site 156
S1655
R
K
A
G
S
S
A
S
P
P
A
P
Y
S
P
Site 157
Y1660
S
A
S
P
P
A
P
Y
S
P
P
S
S
R
P
Site 158
S1661
A
S
P
P
A
P
Y
S
P
P
S
S
R
P
L
Site 159
S1664
P
A
P
Y
S
P
P
S
S
R
P
L
S
S
P
Site 160
S1665
A
P
Y
S
P
P
S
S
R
P
L
S
S
P
L
Site 161
S1669
P
P
S
S
R
P
L
S
S
P
L
D
E
L
A
Site 162
S1670
P
S
S
R
P
L
S
S
P
L
D
E
L
A
S
Site 163
S1677
S
P
L
D
E
L
A
S
L
F
N
S
G
R
S
Site 164
S1681
E
L
A
S
L
F
N
S
G
R
S
V
L
R
K
Site 165
S1684
S
L
F
N
S
G
R
S
V
L
R
K
S
A
A
Site 166
S1689
G
R
S
V
L
R
K
S
A
A
G
R
K
I
R
Site 167
T1703
R
E
A
E
G
F
E
T
N
M
N
I
S
S
R
Site 168
S1708
F
E
T
N
M
N
I
S
S
R
D
D
P
S
T
Site 169
S1714
I
S
S
R
D
D
P
S
T
S
E
I
T
S
E
Site 170
T1715
S
S
R
D
D
P
S
T
S
E
I
T
S
E
T
Site 171
S1716
S
R
D
D
P
S
T
S
E
I
T
S
E
T
Q
Site 172
S1720
P
S
T
S
E
I
T
S
E
T
Q
D
R
N
A
Site 173
S1735
N
N
H
G
I
Q
L
S
N
S
L
S
S
A
I
Site 174
S1739
I
Q
L
S
N
S
L
S
S
A
I
T
A
E
N
Site 175
T1743
N
S
L
S
S
A
I
T
A
E
N
G
N
S
I
Site 176
S1749
I
T
A
E
N
G
N
S
I
S
N
G
L
P
E
Site 177
Y1760
G
L
P
E
E
D
G
Y
S
R
L
S
I
S
G
Site 178
S1761
L
P
E
E
D
G
Y
S
R
L
S
I
S
G
T
Site 179
S1764
E
D
G
Y
S
R
L
S
I
S
G
T
G
T
S
Site 180
S1766
G
Y
S
R
L
S
I
S
G
T
G
T
S
T
F
Site 181
T1768
S
R
L
S
I
S
G
T
G
T
S
T
F
Q
R
Site 182
T1770
L
S
I
S
G
T
G
T
S
T
F
Q
R
H
R
Site 183
S1771
S
I
S
G
T
G
T
S
T
F
Q
R
H
R
D
Site 184
T1772
I
S
G
T
G
T
S
T
F
Q
R
H
R
D
S
Site 185
T1781
Q
R
H
R
D
S
H
T
T
Q
V
I
H
Q
L
Site 186
T1782
R
H
R
D
S
H
T
T
Q
V
I
H
Q
L
R
Site 187
S1795
L
R
L
S
E
N
E
S
V
A
L
Q
E
L
L
Site 188
S1836
P
P
P
C
K
K
P
S
L
L
K
K
P
E
G
Site 189
S1845
L
K
K
P
E
G
A
S
C
N
R
L
P
S
E
Site 190
S1851
A
S
C
N
R
L
P
S
E
L
W
D
T
T
I
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation